在迷你猪模型中,连续发射 1 和 2 兆赫双极微针射频能量对热组织反应的影响。

IF 2 4区 医学 Q3 DERMATOLOGY Skin Research and Technology Pub Date : 2024-09-01 DOI:10.1111/srt.13898
Sung Bin Cho, Sun Young Kang, Yea-Jin Lee, Min Choi, Bora Kim, Jin-Chul Ahn
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引用次数: 0

摘要

背景:双极微针射频(RF)治疗会产生不同模式的热反应,这取决于皮肤阻抗和射频治疗参数,包括频率、功率、传导时间、子脉冲包的设置、穿透深度和使用的微针类型。我们比较了在活体小鼠皮肤上连续发射 1 赫兹和 2 赫兹双极射频能量对热组织反应的影响:方法:将频率为 1 和 2 MHz 的射频依次输送到小鼠的活体皮肤上。方法:将频率为 1 和 2 MHz 的射频依次照射到小猪的活体皮肤上,进行组织学研究,分析射频在治疗后 1 小时、3 天、7 天和 14 天引起的皮肤反应:结果:皮肤样本显示,根据实验设置和组织阻抗的不同,两种不同频率的射频治疗产生了不同模式的电极周围凝固性坏死(PECN)。在 PECN 区域,第一次射频处理引起的组织凝固被后一次另一频率射频处理的影响所包围。在电极间非坏死性热反应区,后一次射频治疗的效果广泛深入真皮层,而真皮层先接受了另一种频率的射频治疗。以 6 或 10 个子脉冲包提供脉冲型射频能量,可在较长的传导时间内有效提供射频能量,而不会对表皮造成过度的热损伤。尽管如此,通过顺序传递两种不同的射频频率,射频引起的组织反应明显增强:结论:1 赫兹和 2 赫兹射频能量的连续传输可诱导组织反应的新组织学模式,从而协同增强每种射频设置的热刺激效应。此外,通过调节射频的频率顺序和子脉冲包的数量,还能产生不同的组织反应模式。
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Effect of sequential delivery of 1- and 2-MHz bipolar microneedling radiofrequency energy on thermal tissue reactions in a minipig model.

Background: Bipolar microneedling radiofrequency (RF) treatment generates different patterns of thermal reactions, depending on the skin impedance and RF treatment parameters, including the frequency, power, conduction time, settings of sub-pulse packs, and penetrating depth and type of microneedles used. We compared the effect of sequential delivery of 1- and 2-MHz bipolar RF energy to in vivo minipig skin on thermal tissue reaction.

Methods: RF treatments at frequencies of 1 and 2 MHz were sequentially delivered to minipigs' skin in vivo. A histological study was performed to analyze RF-induced skin reactions at 1-h and at 3-, 7-, and 14-days post-treatment.

Results: The skin specimens demonstrated that the two different frequencies of RF treatment generated mixed patterns of the peri-electrode coagulative necrosis (PECN) according to the experimental settings and tissue impedance. In the PECN zone, the tissue coagulation induced by the first RF treatment was surrounded by the effect of the later RF treatment at the other RF frequency. In the inter-electrode non-necrotic thermal reaction zone, the effect of the latter RF treatment was widespread and deep through the dermis, which had received RF treatment at the other frequency first. The delivery of pulsed-type RF energy at sub-pulse packs of 6 or 10 provided effective RF delivery over long conduction time without excessive thermal damage of the epidermis. Nonetheless, by sequential delivery of two different RF frequencies, RF-induced tissue reactions were found to be markedly enhanced.

Conclusion: The sequential delivery of 1- and 2-MHz RF energy induces novel histological patterns of tissue reactions, which can synergistically enhance the thermostimulatory effects of each RF setting. Moreover, variations in patterns of tissue reactions can be generated by regulating the order of frequencies and the number of sub-pulse packs of RF used.

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来源期刊
Skin Research and Technology
Skin Research and Technology 医学-皮肤病学
CiteScore
3.30
自引率
9.10%
发文量
95
审稿时长
6-12 weeks
期刊介绍: Skin Research and Technology is a clinically-oriented journal on biophysical methods and imaging techniques and how they are used in dermatology, cosmetology and plastic surgery for noninvasive quantification of skin structure and functions. Papers are invited on the development and validation of methods and their application in the characterization of diseased, abnormal and normal skin. Topics include blood flow, colorimetry, thermography, evaporimetry, epidermal humidity, desquamation, profilometry, skin mechanics, epiluminiscence microscopy, high-frequency ultrasonography, confocal microscopy, digital imaging, image analysis and computerized evaluation and magnetic resonance. Noninvasive biochemical methods (such as lipids, keratin and tissue water) and the instrumental evaluation of cytological and histological samples are also covered. The journal has a wide scope and aims to link scientists, clinical researchers and technicians through original articles, communications, editorials and commentaries, letters, reviews, announcements and news. Contributions should be clear, experimentally sound and novel.
期刊最新文献
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