高功率 675 纳米激光:针对不同皮肤疾病的临床评估和体外证据的安全性和有效性。

IF 2 4区 医学 Q3 DERMATOLOGY Skin Research and Technology Pub Date : 2024-09-01 DOI:10.1111/srt.70019
Massimo D F Vitale, Francesca Madeddu, Irene Fusco, Laura Pieri, Paolo Bonan, Tiziano Zingoni, Giada Magni, Francesca Rossi
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引用次数: 0

摘要

背景:激光技术是治疗色素病变、血管病变和痤疮疤痕等多种皮肤病变的可行疗法。目的:在这项工作中,我们通过体外和临床研究,测试了发射 675 纳米的高功率激光系统治疗各种皮肤病的有效性、安全性和治疗速度:体外实验:用 675 纳米激光对成人真皮成纤维细胞(HDFa)进行 24、48 和 72 小时不同能量的照射,并对 Ki-67+ 细胞进行计数。获得对照组和处理组样本的共聚焦显微镜图像。使用 675 nm 激光设备对 11 名色素病变患者、5 名痤疮疤痕患者和 23 名嫩肤患者进行了不同激光参数的临床嫩肤/疾病治疗。结果显示,使用高功率 675 nm 激光设备治疗色素病变和痤疮疤痕的疗效显著:结果:在体外实验中,高功率 675 nm 激光被证明能有效刺激细胞增殖,对所有皮肤病变都有很好的疗效。GAIS 显示,所有接受治疗的病症的评分都在 3 到 4 分之间,所有评分都在 "75%-良好改善 "和 "100%-极佳改善 "之间。与旧的参数设置相比,治疗时间缩短了 50%,从而实现了更快、更令患者满意的技术。结论:临床前和临床数据证实了这种高功率 675 nm 激光治疗多种皮肤病的有效性和安全性。
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High-powered 675-nm laser: Safety and efficacy in clinical evaluation and in vitro evidence for different skin disorders.

Background: Laser technology is a viable therapeutic option for treating a number of skin pathologic conditions, including pigmented lesions, vascular lesions and acne scars.

Aim: In this work, through in vitro and clinical investigations we test the efficacy, the safety and the speed of treatment of high-powered laser system emitting a 675-nm in the management of various skin condition.

Materials and methods: In vitro experiments were performed irradiating adult human dermal fibroblasts cells (HDFa) with 675-nm laser for 24, 48 and 72 h with different fluences and Ki-67+ cells were counted. The confocal microscopy images of control and treated samples were acquired. Clinical skin rejuvenation/diseases treatments with 675 nm laser device were performed with different laser parameters in 11 patients with pigmented lesions, 5 patients with acne scars and 23 patients for skin rejuvenation. Data were evaluated with the validated global score using 5-point scales (GAIS) and patient's satisfaction scale.

Results: The application of the high-power 675 nm laser has proven effective in stimulating cell proliferation in in vitro experiments and it led to good results for all skin pathologies. GAIS showed values between 3 and 4 points for all treated pathologies, all scores between '75%-good improvements' and '100%-excellent improvements'. The treatment time was reduced by 50% compared to the old parameters setting, resulting in a faster and good patient's satisfying technique. No serious adverse effects were recorded.

Conclusion: the preclinical and clinical data confirm the efficacy and safety of this high-powered 675 nm laser for several skin condition.

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来源期刊
Skin Research and Technology
Skin Research and Technology 医学-皮肤病学
CiteScore
3.30
自引率
9.10%
发文量
95
审稿时长
6-12 weeks
期刊介绍: Skin Research and Technology is a clinically-oriented journal on biophysical methods and imaging techniques and how they are used in dermatology, cosmetology and plastic surgery for noninvasive quantification of skin structure and functions. Papers are invited on the development and validation of methods and their application in the characterization of diseased, abnormal and normal skin. Topics include blood flow, colorimetry, thermography, evaporimetry, epidermal humidity, desquamation, profilometry, skin mechanics, epiluminiscence microscopy, high-frequency ultrasonography, confocal microscopy, digital imaging, image analysis and computerized evaluation and magnetic resonance. Noninvasive biochemical methods (such as lipids, keratin and tissue water) and the instrumental evaluation of cytological and histological samples are also covered. The journal has a wide scope and aims to link scientists, clinical researchers and technicians through original articles, communications, editorials and commentaries, letters, reviews, announcements and news. Contributions should be clear, experimentally sound and novel.
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