烟草重组蛋白生产亚细胞积累设计的进展。

Q2 Agricultural and Biological Sciences 生物设计研究(英文) Pub Date : 2024-08-28 eCollection Date: 2024-01-01 DOI:10.34133/bdr.0047
Shi-Jian Song, Hai-Ping Diao, Yong-Feng Guo, Inhwan Hwang
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引用次数: 0

摘要

植物及其作为生物反应器用于生产重组蛋白已成为植物生物技术和植物合成生物学领域最热门的话题之一。与其他类型的生物反应器相比,植物生物反应器具有更优越的工程潜力,特别是在提高产量和质量的亚细胞积累策略领域。本综述探讨了烟草生物反应器中重组蛋白亚细胞积累的既有和新兴策略,重点介绍了该领域的最新进展。此外,综述还介绍了为目标蛋白质选择最佳亚细胞定位这一关键的初始步骤,这一设计对生产结果有重大影响。
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Advances in Subcellular Accumulation Design for Recombinant Protein Production in Tobacco.

Plants and their use as bioreactors for the generation of recombinant proteins have become one of the hottest topics in the field of Plant Biotechnology and Plant Synthetic Biology. Plant bioreactors offer superior engineering potential compared to other types, particularly in the realm of subcellular accumulation strategies for increasing production yield and quality. This review explores established and emerging strategies for subcellular accumulation of recombinant proteins in tobacco bioreactors, highlighting recent advancements in the field. Additionally, the review provides reference to the crucial initial step of selecting an optimal subcellular localization for the target protein, a design that substantially impacts production outcomes.

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CiteScore
3.90
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0.00%
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12 weeks
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