在所有正确的地方寻找睡眠:我的睡眠研究生涯

Priyattam J Shiromani
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引用次数: 0

摘要

我的研究一直以睡眠为重点,无论是监测神经活动(微线、c-Fos、钙成像),用光遗传学或药理学方法(肾上腺酰胺、胆碱能激动剂)触发睡眠,还是测量腺苷等内源性睡眠因子的水平。我研究的一个经常性主题是利用新工具找到大脑中睡眠信号开始的甜点。我的目标是找出这一电路,确定它是否会随着年龄增长或疾病而退化,并在电路失效时对其进行修复。我衷心感谢我的导师向我介绍睡眠科学,感谢我的学生和同事帮助我进行探索,感谢美国国立卫生研究院(NIH)和退伍军人事务部(VA Research)对研究工作的支持。由于睡眠研究人员的共同努力,公众更加意识到睡眠对健康生活方式的重要性。
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Searching for sleep in all the right places: My career in sleep research.

My research has always focused on sleep, whether monitoring neural activity (microwires, c-Fos, calcium imaging), triggering it with optogenetics or pharmacologically (anandamide, cholinergic agonists), or measuring levels of endogenous sleep agents such as adenosine. A recurring theme of my research is to use new tools to find the sweet spot in the brain where the signal to sleep begins. My goal is to identify the circuit, determine whether it degrades with age or disease, and repair the circuit when it fails. I am deeply grateful to my mentors for introducing me to the science of sleep, to my students and colleagues for helping me in my quest, and to the NIH and VA Research for supporting the research. Because of the collective efforts of sleep researchers, the public is more aware of the importance of sleep to a healthy lifestyle.

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A life of research on everyday sleep(iness). How openness and inquisitiveness led to a career as a sleep researcher and a broad contribution to sleep science. The lasting legacy of Charles Fisher (1908-1988), pioneering sleep laboratory scientist and sleep medicine psychiatrist. How did I come to sleep research and stay there? Looking beyond sleep duration in understanding obesity risk in adolescents: the role of circadian timing and misalignment on adolescent dietary outcomes, physical activity, and body mass index.
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