CD31 对冠状动脉侧支发育的影响

Huseyin Akcali, Mustafa Begenc Tascanov, Kenan Toprak, Halil Fedai, Asuman Bicer, İbrahim Halil Altiparmak, Zulkif Tanriverdi, Recep Demirbag, Ismail Koyuncu
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引用次数: 0

摘要

背景:研究表明,侧支的发展对心肌功能起着至关重要的作用,尤其是在冠状动脉疾病患者中。然而,这些侧支的演变尚未得到充分解释:本研究旨在揭示 CD31 对冠状动脉侧支发展的影响:方法:本诊所对 89 名冠心病患者和 90 名冠状动脉正常的患者进行了冠状动脉造影。根据受试者的血管造影图像记录侧支发育程度。比较冠状动脉疾病组和对照组的 CD31 值。此外,根据侧支发育情况将冠状动脉疾病组分为侧支发育良好和侧支发育不良两组,并尝试确定可能影响侧支发育的因素:结果:与对照组相比,冠心病组的 CD31 水平明显升高(PCD31是血管生成的标志物,可能与冠状动脉侧支的发育有关。
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The Effect of CD31 on Coronary Collateral Development.

Background: Coronary collaterals are the feeding bridges between the main epicardial arteries, and research has shown that this collateral development plays a crucial role in myocardial performance, especially in patients with coronary artery disease. However, the evolution of these collaterals has not been fully explained.

Objective: In this study, we aimed to reveal the effect of CD31 on coronary collateral development.

Methods: As a result of coronary angiography performed in our clinic, 89 patients with coronary artery disease and 90 patients with normal coronary arteries were included in the study. Collateral development degrees were recorded from the angiographic images of the subjects. CD31 values were compared between the group with coronary artery disease and the control group. In addition, the coronary artery disease group was divided into subgroups according to the collateral development in terms of good collateral development and poor collateral development, and the factors that may affect the collateral development were tried to be determined.

Results: CD31 levels were significantly higher in the group with coronary artery disease compared to the control group (p <0.001). In addition, CD31 levels in the subgroup with good collateral were significantly higher than in the group with weak collateral (p <0.001). In the correlation analysis, a significant positive correlation was found between serum CD31 level and SYNTAX score, age, glucose, and rentrop grade. Multivariate logistic regression analysis showed CD31 to be an independent predictor of good coronary collateral development.

Conclusion: CD31, a marker of angiogenesis, may be involved in coronary collateral development.

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