有关 COVID-19 疫苗实验毒性研究的科学文献综述,特别关注在毒理学期刊上发表的文章。

IF 4.8 2区 医学 Q1 TOXICOLOGY Archives of Toxicology Pub Date : 2024-09-03 DOI:10.1007/s00204-024-03854-8
Jose L. Domingo
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引用次数: 0

摘要

自报告第一例 COVID-19 病例以来,在不到 5 年的时间里,有关该疾病和造成感染的冠状病毒(SARS-CoV-2)的大量文件已经出版。大量科学文献涵盖了与 COVID-19/SARS-CoV-2 直接相关的不同问题的许多专题。报告已批准的 COVID-19 疫苗的不良/副作用的文章(包括综述)数量可观。据报道,人类接种 COVID-19 疫苗后出现了多种不良/副作用:血栓事件/血小板减少症、心肌炎/心包炎、皮肤反应、免疫介导效应、精神不良事件、系统性红斑狼疮、生殖毒性以及其他各种不良反应。相比之下,为评估 COVID-19 疫苗在实验动物中的潜在毒性/不良反应而进行的非临床研究的信息则非常稀少。本综述旨在修订有关 COVID-19 疫苗在实验动物中毒性/不良反应研究的科学文献。此外,还对影响因子最高的特定毒理学期刊上的研究报告进行了逐一审查。本综述的结果表明,大多数关于 COVID-19 疫苗和/或潜在候选疫苗不良/毒性作用的非临床/实验研究总体上显示出良好的安全性。只有在一些动物实验中发现了某些不良反应。然而,一个令人惊讶的结果是,世界上最大的 mRNA 疫苗生产商所进行的非临床研究数量有限(在 PubMed 和 Scopus 数据库中)。这些研究应该已经进行过。然而,这些研究并未在科学杂志上发表,这就无法让包括毒理学专家在内的国际科学界作出判断。
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A review of the scientific literature on experimental toxicity studies of COVID-19 vaccines, with special attention to publications in toxicology journals

Since the reports of the first cases of COVID-19, in less than 5 years, a huge number of documents regarding that disease and the coronavirus (SARS-CoV-2), responsible for the infection, have been published. The tremendous number of scientific documents covers many topics on different issues directly related to COVID-19/SARS-CoV-2. The number of articles—including reviews—reporting adverse/side effects of the approved COVID-19 vaccines is considerable. A wide range of adverse/side effects have been reported in humans after COVID-19 vaccination: thrombotic events/thrombocytopenia, myocarditis/pericarditis, cutaneous reactions, immune-mediated effects, psychiatric adverse events, systemic lupus erythematosus, reproductive toxicity, and other miscellaneous adverse effects. In contrast, information on nonclinical studies conducted to assess the potential toxicity/adverse effects of the COVID-19 vaccines in laboratory animals, is comparatively very scarce. The present review was aimed at revising the scientific literature regarding the studies in laboratory animals on the toxic/adverse effects of COVID-19 vaccines. In addition, the investigations reported in those specific toxicology journals with the highest impact factors have been examined one by one. The results of the present review indicate that most nonclinical/experimental studies on the adverse/toxic effects of the COVID-19 vaccines and/or potential candidates showed—in general terms—a good safety profile. Only in some animal studies were certain adverse effects found. However, a rather surprising result has been the limited number of available (in the databases PubMed and Scopus) nonclinical studies performed by the companies that have been the largest manufacturers of mRNA vaccines in the world. It is assumed that these studies have been conducted. However, they have not been published in scientific journals, which does not allow the judgment of the international scientific community, including toxicologists.

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来源期刊
Archives of Toxicology
Archives of Toxicology 医学-毒理学
CiteScore
11.60
自引率
4.90%
发文量
218
审稿时长
1.5 months
期刊介绍: Archives of Toxicology provides up-to-date information on the latest advances in toxicology. The journal places particular emphasis on studies relating to defined effects of chemicals and mechanisms of toxicity, including toxic activities at the molecular level, in humans and experimental animals. Coverage includes new insights into analysis and toxicokinetics and into forensic toxicology. Review articles of general interest to toxicologists are an additional important feature of the journal.
期刊最新文献
Heavy metals: toxicity and human health effects. Design of optimal concentrations for in vitro cytotoxicity experiments. Drug-induced cholestasis (DIC) predictions based on in vitro inhibition of major bile acid clearance mechanisms. Antineoplastic therapy affects the in vitro phenotype and functionality of healthy human bone marrow-derived mesenchymal stromal cells. Maternal probiotic supplementation protects against PBDE-induced developmental, behavior and metabolic reprogramming in a sexually dimorphic manner: Role of gut microbiome.
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