人类 E3 泛素连接酶:SARS-CoV-2 感染的加速器和制动器。

IF 3.8 3区 生物学 Q2 BIOCHEMISTRY & MOLECULAR BIOLOGY Biochemical Society transactions Pub Date : 2024-10-30 DOI:10.1042/BST20230324
Jesse Pellman, Anna Goldstein, Mikołaj Słabicki
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引用次数: 0

摘要

E3 泛素连接酶调节蛋白质组的组成。这些酶对它们的底物进行单泛素化或多泛素化,直接改变蛋白质的功能,或将蛋白质作为靶标由蛋白酶体降解。在这篇综述中,我们将讨论人类 E3 连接酶在宿主与病原体之间的进化之战中作为效应器和靶标的对立作用,特别是在 SARS-CoV-2 感染的背景下。通过对转录、翻译和蛋白质运输的复杂影响,人类 E3 连接酶既可以减轻 SARS-CoV-2 感染,也可以成为病毒利用来抑制宿主抗病毒防御的漏洞。例如,人类 E3 连接酶 RNF185 通过泛素-蛋白酶体途径调节 SARS-CoV-2 包膜蛋白的稳定性,RNF185 的缺失会显著增加 SARS-CoV-2 病毒的滴度(iScience (2023) 26, 106601)。我们重点介绍了最近的研究进展,这些进展确定了许多人类 E3 连接酶在 SARS-CoV-2 生命周期中的功能,我们还评估了它们作为新型抗病毒药物的潜力。
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Human E3 ubiquitin ligases: accelerators and brakes for SARS-CoV-2 infection.

E3 ubiquitin ligases regulate the composition of the proteome. These enzymes mono- or poly-ubiquitinate their substrates, directly altering protein function or targeting proteins for degradation by the proteasome. In this review, we discuss the opposing roles of human E3 ligases as effectors and targets in the evolutionary battle between host and pathogen, specifically in the context of SARS-CoV-2 infection. Through complex effects on transcription, translation, and protein trafficking, human E3 ligases can either attenuate SARS-CoV-2 infection or become vulnerabilities that are exploited by the virus to suppress the host's antiviral defenses. For example, the human E3 ligase RNF185 regulates the stability of SARS-CoV-2 envelope protein through the ubiquitin-proteasome pathway, and depletion of RNF185 significantly increases SARS-CoV-2 viral titer (iScience (2023) 26, 106601). We highlight recent advances that identify functions for numerous human E3 ligases in the SARS-CoV-2 life cycle and we assess their potential as novel antiviral agents.

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来源期刊
Biochemical Society transactions
Biochemical Society transactions 生物-生化与分子生物学
CiteScore
7.80
自引率
0.00%
发文量
351
审稿时长
3-6 weeks
期刊介绍: Biochemical Society Transactions is the reviews journal of the Biochemical Society. Publishing concise reviews written by experts in the field, providing a timely snapshot of the latest developments across all areas of the molecular and cellular biosciences. Elevating our authors’ ideas and expertise, each review includes a perspectives section where authors offer comment on the latest advances, a glimpse of future challenges and highlighting the importance of associated research areas in far broader contexts.
期刊最新文献
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