Ahmed Barhoum, Yaser Alhashemi, Yomna M Ahmed, Mahmoud S Rizk, Mikhael Bechelany, Fatehy M Abdel-Haleem
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引用次数: 0
摘要
近年来,在创新性现代设计和纳米材料集成的推动下,离子选择性光电极(ISO)取得了显著进展。本综述通过介绍提高其灵敏度、选择性和实时监测能力的最新策略,探讨了现代光电二极管的发展。综述报告了传统的基于膜的光学传感器,并调查了最新的研究、当前的设计原则以及在 ISO 制造中使用的重要成分,如离子体、指示染料、聚合物膜和纳米材料。会议特别关注纳米材料(如量子点、聚合物点、纳米球、纳米棒和纳米胶囊),尤其是稀土元素如何进一步增强其潜力。会议还介绍了创新的 ISO 设计,包括可穿戴式光学器件、智能手机光学器件和一次性纸质光学器件。随着人们对高灵敏度、高选择性和高适应性离子传感设备的不断追求,本报告总结了当前的知识,为不同领域(药物制剂、医疗诊断、环境监测和工业应用)即将出现的创新和应用奠定了基础。
Innovations in ion-selective optodes: a comprehensive exploration of modern designs and nanomaterial integration.
In recent years, ion-selective optodes (ISOs) have remarkably progressed, driven by innovative modern designs and nanomaterial integration. This review explored the development of modern ISO by describing state-of-the-art strategies to improve their sensitivity, selectivity, and real-time monitoring capacity. The review reported the traditional membrane based-optodes, and investigated the latest research, current design principles, and the use of essential components, such as ionophores, indicator dyes, polymer membranes, and nanomaterials, in ISO fabrication. Special attention was given to nanomaterials (e.g., quantum dots, polymer dots, nanospheres, nanorods and nanocapsules) and particularly on how rare earth elements can further enhance their potential. It also described innovative ISO designs, including wearable optodes, smartphone-based optodes, and disposable paper-based optodes. As the pursuit of highly sensitive, selective, and adaptable ion sensing devices continues, this summary of the current knowledge sets the stage for upcoming innovations and applications in different domains (pharmaceutical formulations, medical diagnosis, environmental monitoring, and industrial applications).
期刊介绍:
The translation of new discoveries in medicine to clinical routine has never been easy. During the second half of the last century, thanks to the progress in chemistry, biochemistry and pharmacology, we have seen the development and the application of a large number of drugs and devices aimed at the treatment of symptoms, blocking unwanted pathways and, in the case of infectious diseases, fighting the micro-organisms responsible. However, we are facing, today, a dramatic change in the therapeutic approach to pathologies and diseases. Indeed, the challenge of the present and the next decade is to fully restore the physiological status of the diseased organism and to completely regenerate tissue and organs when they are so seriously affected that treatments cannot be limited to the repression of symptoms or to the repair of damage. This is being made possible thanks to the major developments made in basic cell and molecular biology, including stem cell science, growth factor delivery, gene isolation and transfection, the advances in bioengineering and nanotechnology, including development of new biomaterials, biofabrication technologies and use of bioreactors, and the big improvements in diagnostic tools and imaging of cells, tissues and organs.
In today`s world, an enhancement of communication between multidisciplinary experts, together with the promotion of joint projects and close collaborations among scientists, engineers, industry people, regulatory agencies and physicians are absolute requirements for the success of any attempt to develop and clinically apply a new biological therapy or an innovative device involving the collective use of biomaterials, cells and/or bioactive molecules. “Frontiers in Bioengineering and Biotechnology” aspires to be a forum for all people involved in the process by bridging the gap too often existing between a discovery in the basic sciences and its clinical application.