阿格马丁对帕金森病的神经保护作用:关注氧化应激、炎症和分子机制。

IF 4.5 2区 医学 Q2 CELL BIOLOGY Inflammation Pub Date : 2024-09-03 DOI:10.1007/s10753-024-02139-7
Mohammad Yasin Zamanian, Mozhgan Nazifi, Lusine G Khachatryan, Niloofar Taheri, Mehraveh Sadeghi Ivraghi, Soumya V Menon, Beneen Husseen, K D V Prasad, Iliya Petkov, Nikta Nikbakht
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摘要

阿格马丁(AGM)是一种天然多胺,由 L-精氨酸衍生而来,由于其具有多方面的生物活性,包括抗氧化、抗炎和抗细胞凋亡作用,已显示出治疗帕金森病(PD)的巨大潜力。本综述探讨了 AGM 在治疗帕金森病方面的治疗潜力,重点关注其神经保护机制和临床前研究证据。在动物模型中,AGM 可通过改善运动功能、减少氧化应激标记物和降低促炎细胞因子水平来减轻鱼藤酮(ROT)的神经毒性作用。此外,AGM 还能防止对多巴胺合成至关重要的 TH + 神经元的丧失。AGM 的神经保护特性归因于它能够调节与帕金森病发病机制有关的几种关键通路,如抑制 NMDA 受体、激活 Nrf2 和抑制 HMGB1/ RAGE/ TLR4/ MyD88/ NF-κB 信号级联。此外,阿马汀在增强神经可塑性要素(如 CREB、BDNF 和 ERK1/2)方面的作用也凸显了其促进神经恢复的潜力。这篇综述强调了γ-巴马汀在帕金森病治疗中的治疗潜力,认为它既能缓解症状,又能保护神经,从而改变病程并改善患者的生活质量。要将这些临床前研究结果转化为临床应用,还需要进一步的研究。
本文章由计算机程序翻译,如有差异,请以英文原文为准。

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The Neuroprotective Effects of Agmatine on Parkinson's Disease: Focus on Oxidative Stress, Inflammation and Molecular Mechanisms.

Agmatine (AGM), a naturally occurring polyamine derived from L-arginine, has shown significant potential for neuroprotection in Parkinson's Disease (PD) due to its multifaceted biological activities, including antioxidant, anti-inflammatory, and anti-apoptotic effects. This review explores the therapeutic potential of AGM in treating PD, focusing on its neuroprotective mechanisms and evidence from preclinical studies. AGM has been demonstrated to mitigate the neurotoxic effects of rotenone (ROT) by improving motor function, reducing oxidative stress markers, and decreasing levels of pro-inflammatory cytokines in animal models. Additionally, AGM protects against the loss of TH + neurons, crucial for dopamine synthesis. The neuroprotective properties of AGM are attributed to its ability to modulate several key pathways implicated in PD pathogenesis, such as inhibition of NMDA receptors, activation of Nrf2, and suppression of the HMGB1/ RAGE/ TLR4/ MyD88/ NF-κB signaling cascade. Furthermore, the potential of agmatine to promote neurorestoration is highlighted by its role in enhancing neuroplasticity elements such as CREB, BDNF, and ERK1/2. This review highlights agmatine's promising therapeutic potential in PD management, suggesting that it could offer both symptomatic relief and neuroprotective benefits, thereby modifying the disease course and improving the quality of life for patients. Further research is warranted to translate these preclinical findings into clinical applications.

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来源期刊
Inflammation
Inflammation 医学-免疫学
CiteScore
9.70
自引率
0.00%
发文量
168
审稿时长
3.0 months
期刊介绍: Inflammation publishes the latest international advances in experimental and clinical research on the physiology, biochemistry, cell biology, and pharmacology of inflammation. Contributions include full-length scientific reports, short definitive articles, and papers from meetings and symposia proceedings. The journal''s coverage includes acute and chronic inflammation; mediators of inflammation; mechanisms of tissue injury and cytotoxicity; pharmacology of inflammation; and clinical studies of inflammation and its modification.
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