1型先天性淋巴细胞:肉样瘤病的生物标志物和候选疗法。

IF 13.3 1区 医学 Q1 MEDICINE, RESEARCH & EXPERIMENTAL Journal of Clinical Investigation Pub Date : 2024-09-03 DOI:10.1172/JCI183708
Inchul Cho, Andrew L Ji
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引用次数: 0

摘要

肉样瘤病是一种炎症性疾病,其特征是在多个器官中形成富含免疫细胞的肉芽肿。在本期 JCI 杂志上,Sati 及其同事利用 scRNA-seq 和空间转录组学对肉样瘤病和非肉样瘤病肉芽肿病患者的皮肤样本进行了研究,发现肉样瘤病中基质-免疫 CXCL12/CXCR4 轴上调和 1 型先天性淋巴细胞(ILC1s)聚集。ILC1s在皮肤和血液中的积聚是肉样瘤病患者特有的,在其他肉芽肿疾病中没有观察到。作者利用小鼠肺肉芽肿模型表明,ILCs 有助于肉芽肿的形成,而阻断 CXCR4 可减少肉芽肿的形成,从而证明了可以通过阻断 CXCR4 来治疗肉样瘤病,防止患者病情恶化。这些结果表明,ILC1s 可作为肉样瘤病的诊断生物标志物和潜在的治疗靶点。
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Type 1 innate lymphoid cells: a biomarker and therapeutic candidate in sarcoidosis.

Sarcoidosis is an inflammatory disease characterized by immune cell-rich granulomas that form in multiple organs. In this issue of the JCI, Sati and colleagues used scRNA-seq and spatial transcriptomics of skin samples from patients with sarcoidosis and non-sarcoidosis granulomatous disease to identify upregulation of a stromal-immune CXCL12/CXCR4 axis and accumulation of type 1 innate lymphoid cells (ILC1s) in sarcoidosis. The accumulation of ILC1s in skin and blood was specific to patients with sarcoidosis and not observed in other granulomatous diseases. The authors used a mouse model of lung granuloma to show that ILCs contribute to granuloma formation and that blockade of CXCR4 reduced the formation of granulomas, providing a proof of concept that sarcoidosis may be treated by CXCR4 blockade to prevent the progression of disease in patients. These results suggest ILC1s could serve as a diagnostic biomarker in sarcoidosis and a potential therapeutic target.

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来源期刊
Journal of Clinical Investigation
Journal of Clinical Investigation 医学-医学:研究与实验
CiteScore
24.50
自引率
1.30%
发文量
1034
审稿时长
2 months
期刊介绍: The Journal of Clinical Investigation, established in 1924 by the ASCI, is a prestigious publication that focuses on breakthroughs in basic and clinical biomedical science, with the goal of advancing the field of medicine. With an impressive Impact Factor of 15.9 in 2022, it is recognized as one of the leading journals in the "Medicine, Research & Experimental" category of the Web of Science. The journal attracts a diverse readership from various medical disciplines and sectors. It publishes a wide range of research articles encompassing all biomedical specialties, including Autoimmunity, Gastroenterology, Immunology, Metabolism, Nephrology, Neuroscience, Oncology, Pulmonology, Vascular Biology, and many others. The Editorial Board consists of esteemed academic editors who possess extensive expertise in their respective fields. They are actively involved in research, ensuring the journal's high standards of publication and scientific rigor.
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