成功利用局部曲美替尼治疗神经纤维瘤病Ⅰ型相关丛状神经纤维瘤。

IF 1.2 4区医学 Q3 DERMATOLOGY Pediatric Dermatology Pub Date : 2024-11-01 Epub Date: 2024-09-03 DOI:10.1111/pde.15710

Leonid Melnikov, Lars Brichta, Nathan J Schloemer

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引用次数: 0

摘要

一名患有神经纤维瘤病 1 型（NF-1）和视神经胶质瘤病史的 11 岁女性出现了进行性乳房皮肤丛状神经纤维瘤。该病变接受了丝裂原活化蛋白激酶抑制剂曲美替尼的局部治疗，结果皮肤丛状神经纤维瘤在两年多的时间里病情稳定，没有进展。该病例表明，局部应用曲美替尼治疗与 NF1 相关的浅表皮肤丛状神经纤维瘤具有潜力，而且不会产生与全身治疗相关的毒性。

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Successful utilization of topical trametinib for neurofibromatosis type I-associated plexiform neurofibroma.

An 11-year-old female with neurofibromatosis type 1 (NF-1) and history of optic glioma presented with a progressive cutaneous plexiform neurofibroma of the breast. The lesion was treated with topical application of a mitogen-activated protein kinase inhibitor, trametinib, resulting in stable, non-progression cutaneous plexiform neurofibroma for greater than 2 years. This case demonstrates the potential application of topical trametinib for NF1-associated superficial cutaneous plexiform neurofibroma without the toxicities associated with systemic treatment.

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来源期刊

Pediatric Dermatology 医学-皮肤病学

CiteScore

3.20

自引率

6.70%

发文量

269

审稿时长

1 months

期刊介绍： Pediatric Dermatology answers the need for new ideas and strategies for today''s pediatrician or dermatologist. As a teaching vehicle, the Journal is still unsurpassed and it will continue to present the latest on topics such as hemangiomas, atopic dermatitis, rare and unusual presentations of childhood diseases, neonatal medicine, and therapeutic advances. As important progress is made in any area involving infants and children, Pediatric Dermatology is there to publish the findings.