与肿瘤转移有关的糖酵解过程的最新进展。

Luo Qiong, Xiao Shuyao, Xu Shan, Fu Qian, Tan Jiaying, Xiao Yao, Ling Hui
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引用次数: 0

摘要

癌症相关死亡的主要原因是癌症转移到身体其他部位,而糖酵解的增加对癌细胞维持其生长和能量需求的高水平至关重要,最终会促进肿瘤的侵袭和扩散。沃伯格效应在癌症的发展过程中起着重要作用,而重点抑制有氧糖酵解可为抗癌治疗提供一种前景广阔的策略。各种糖酵解过程都与肿瘤转移有关,主要涉及非编码 RNA(ncRNA)、信号通路、转录因子等。各类非编码 RNA,包括微 RNA(miRNA)、长非编码 RNA(lncRNA)和环状 RNA(circRNA),在影响与肿瘤扩散相关的糖代谢方面已显示出前景。此外,环状 RNA(circRNA)和长非编码 RNA(lncRNA)主要作为竞争性内源性 RNA(ceRNA),通过封存 microRNA,从而调节靶基因的表达,对癌细胞的代谢过程产生重大影响。此外,通过糖酵解实现肿瘤转移的过程还包括各种信号通路(如 PI3K/AKT、HIF、Wnt/β- Catenin 和 ERK 等)和转录因子。本文描述了非编码 RNA、信号通路和转录因子在肿瘤转移中促进糖酵解的主要机制。文章还探讨了这些因子作为预后标志物和癌症治疗靶点的潜在用途。手稿还探讨了特定中药和临床西药在通过糖酵解机制抑制肿瘤扩散方面的创新应用,为抗癌药物提供了新的候选药物潜力。
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Recent Advances in the Glycolytic Processes Linked to Tumor Metastasis.

The main cause of cancer-related fatalities is cancer metastasis to other body parts, and increased glycolysis is crucial for cancer cells to maintain their elevated levels of growth and energy requirements, ultimately facilitating the invasion and spread of tumors. The Warburg effect plays a significant role in the advancement of cancer, and focusing on the suppression of aerobic glycolysis could offer a promising strategy for anti-cancer treatment. Various glycolysis processes are associated with tumor metastasis, primarily involving non-coding RNA (ncRNAs), signaling pathways, transcription factors, and more. Various categories of noncoding RNAs, including microRNAs (miRNAs), long noncoding RNAs (lncRNAs), and circular RNAs (circRNAs), have shown promise in influencing glucose metabolism associated with the spread of tumors. Additionally, circular RNAs (circRNAs) and long non-coding RNAs (lncRNAs) predominantly act as competitive endogenous RNAs (ceRNAs) by sequestering microRNAs, thereby modulating the expression of target genes and exerting significant influence on the metabolic processes of cancerous cells. Furthermore, the process of tumor metastasis through glycolysis also encompasses various signaling pathways (such as PI3K/AKT, HIF, Wnt/β- Catenin, and ERK, among others) and transcription factors. This article delineates the primary mechanisms through which non-coding RNAs, signaling pathways, and transcription factors contribute to glycolysis in tumor metastasis. It also investigates the potential use of these factors as prognostic markers and targets for cancer treatment. The manuscript also explores the innovative applications of specific traditional Chinese medicine and clinical Western medications in inhibiting tumor spread through glycolysis mechanisms, offering potential as new candidates for anti-cancer drugs.

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