肝病中钠和液体潴留的新机制

IF 28.6 1区 医学 Q1 UROLOGY & NEPHROLOGY Nature Reviews Nephrology Pub Date : 2024-09-03 DOI:10.1038/s41581-024-00892-4
Ellen F. Carney
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引用次数: 0

摘要

肝病患者的钠和液体潴留通常是由于有效血容量减少,从而刺激了肾素-血管紧张素-醛固酮系统(RAAS)。然而,并非所有患者都表现出 RAAS 激活。研究人员得出结论认为,胆汁酸激活ENaC很可能是肝病患者Na+和体液潴留的原因。他们建议在临床治疗中考虑这一机制,尤其是在对螺内酯缺乏反应时。
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A novel mechanism of sodium and fluid retention in liver disease
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来源期刊
Nature Reviews Nephrology
Nature Reviews Nephrology 医学-泌尿学与肾脏学
CiteScore
39.00
自引率
1.20%
发文量
127
审稿时长
6-12 weeks
期刊介绍: Nature Reviews Nephrology aims to be the premier source of reviews and commentaries for the scientific communities it serves. It strives to publish authoritative, accessible articles. Articles are enhanced with clearly understandable figures, tables, and other display items. Nature Reviews Nephrology publishes Research Highlights, News & Views, Comments, Reviews, Perspectives, and Consensus Statements. The content is relevant to nephrologists and basic science researchers. The broad scope of the journal ensures that the work reaches the widest possible audience.
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