膳食抗氧化剂对同时暴露于塑料添加剂和糖尿病之间关联的潜在机制和调节作用。

IF 4.6 2区 医学 Q1 ENDOCRINOLOGY & METABOLISM Nutrition & Diabetes Pub Date : 2024-09-03 DOI:10.1038/s41387-024-00330-1
Yang Yang, Cheng Zhang, Hui Gao
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引用次数: 0

摘要

背景:塑料添加剂混合物暴露与糖尿病的关系以及膳食抗氧化剂的调节作用尚不清楚:方法:检索2011-2018年NHANES数据,选择邻苯二甲酸盐和有机磷酸酯(OPEs)作为暴露物。通过环境风险评分(ERS)和量子 g 计算分析了共同暴露效应。为减少使用内部权重可能造成的偏差,使用交叉验证方法构建了另一个版本的 ERS。膳食抗氧化剂摄入水平通过膳食抗氧化剂综合指数(CDAI)来衡量。结果显示,15 种化学物质(10 种邻苯二甲酸盐)与膳食中抗氧化剂的摄入量存在关联:结果:对 2824 名成年参与者的 15 种化学物质(10 种邻苯二甲酸盐和 5 种 OPE)进行了测量。较高的ERS与糖尿病风险的增加有明显关联(ERS每增加1-SD的OR:1.25,95% CI:1.13-1.39)。这种关联显然与 CDAI 水平相互影响(ORlow:1.83,95% CI:1.37-2.55;ORhigh:1.28,95% CI:1.15-1.45;Pinteraction = 0.038)。此外,量子 g 计算还显示,较高水平的综合暴露与糖尿病呈正相关(OR:1.27,95% CI:1.05-2.87),而添加膳食抗氧化剂与糖尿病呈负相关(OR:1.09,95% CI:0.85-2.34)。AOP 研究发现,TCPP 和 TCEP 是导致糖代谢和胰岛素信号通路异常并导致糖尿病的主要化学物质:邻苯二甲酸盐和 OPEs 的共同暴露与糖尿病呈正相关,而抗氧化饮食可起到调节作用。AOP 框架提出了几种潜在机制。
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Potential mechanisms and modifications of dietary antioxidants on the associations between co-exposure to plastic additives and diabetes.

Background: The association of plastic additive mixture exposure with diabetes and the modifying effects of dietary antioxidants are unclear.

Methods: The data from the NHANES 2011-2018 were retrieved, and phthalates and organophosphate esters (OPEs) were selected as exposures. The coexposure effect was analyzed by the environmental risk score (ERS) and quantile g-computation. To mitigate any potential bias caused by using the internal weights, another version of ERS was constructed using the cross-validation approach. The level of dietary antioxidant intake was measured by the composite dietary antioxidant index (CDAI). The biological mechanism underlying the association was studied by the adverse outcome pathway (AOP) framework.

Results: Fifteen chemicals (ten phthalates and five OPEs) were measured in 2824 adult participants. A higher ERS was significantly associated with an increased risk of diabetes (OR per 1-SD increment of ERS: 1.25, 95% CI: 1.13-1.39). This association apparently interacted with the CDAI level (ORlow: 1.83, 95% CI: 1.37-2.55; ORhigh: 1.28, 95% CI: 1.15-1.45; Pinteraction = 0.038). Moreover, quantile g-computation also revealed higher level of combined exposure was positively associated with diabetes (OR: 1.27, 95% CI: 1.05-2.87), and the addition of dietary antioxidants showed a null association (OR: 1.09, 95% CI: 0.85-2.34). The AOP study identified TCPP and TCEP as key chemicals that cause aberrant glucose metabolism and insulin signaling pathways and result in diabetes.

Conclusions: Coexposure to phthalates and OPEs is positively associated with diabetes, where an antioxidative diet plays a modifying role. Several potential mechanisms have been proposed by AOP framework.

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来源期刊
Nutrition & Diabetes
Nutrition & Diabetes ENDOCRINOLOGY & METABOLISM-NUTRITION & DIETETICS
CiteScore
9.20
自引率
0.00%
发文量
50
审稿时长
>12 weeks
期刊介绍: Nutrition & Diabetes is a peer-reviewed, online, open access journal bringing to the fore outstanding research in the areas of nutrition and chronic disease, including diabetes, from the molecular to the population level.
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