Aymeric Becq, Reena Sidhu, Lia C M J Goltstein, Xavier Dray
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引用次数: 0
摘要
胃肠道血管增生症(GIA)是一种常见的后天性消化道血管异常,也是出血的常见原因。难治性 GIA 的标准通常包括反复出血、输血和/或重复内镜检查。药物和介入治疗是近期发表的高质量论文的主题。本综述概述了难治性 GIA 非内镜治疗的最新进展。主动脉瓣置换术已在海德综合征中显示出其疗效,如有适应症,应考虑进行主动脉瓣置换术。奥曲肽和沙利度胺等抗血管生成药物是治疗难治性 GIA 相关出血的有效药物。根据疗效和耐受性,应首先考虑使用体生长抑素类似物。未来,更好地了解 GIA 的生理病理可能有助于开发新的靶向疗法。
Recent advances in the treatment of refractory gastrointestinal angiodysplasia.
Gastrointestinal angiodysplasia (GIA) is a common, acquired, vascular abnormality of the digestive tract, and a frequent cause of bleeding. Refractory GIA criteria usually include recurrent bleeding, transfusions and/or repeat endoscopy. Pharmacological and interventional treatments have been the subject of recent high-quality publications. This review provides an overview of the latest updates on non-endoscopic management of refractory GIA. Aortic valve replacement has shown its efficacy in Heyde syndrome and should be considered if indicated. Anti-angiogenic drugs, such as Octreotide and Thalidomide, are efficient treatments of refractory GIA-related bleeding. Somatostatin analogs should, based on efficacy and tolerance profile, be considered first. In the future, a better understanding of the physiopathology of GIA might help develop new-targeted therapies.
期刊介绍:
United European Gastroenterology Journal (UEG Journal) is the official Journal of the United European Gastroenterology (UEG), a professional non-profit organisation combining all the leading European societies concerned with digestive disease. UEG’s member societies represent over 22,000 specialists working across medicine, surgery, paediatrics, GI oncology and endoscopy, which makes UEG a unique platform for collaboration and the exchange of knowledge.