Firaol Guyassa Dandena, Berhanetsehay Teklemariam Teklewold, Tadele Dana Darebo, Yisihak Debodina Suga
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We followed the Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) guideline to identify, search, extract articles, and report this systematic review. The protocol was registered in PROSPERO, ID: CRD42023403320.</p><p><strong>Results: </strong>Twenty studies were included in the review with 33,369 participants and 3 were community-based and 17 were hospital-based. In all except two reviewed studies, breast cancer is the most common cancer among women of Ethiopia. The most frequent presenting symptom was a breast lump/mass and commonly affected side was right breast. Most patients presented at a late stage and they were premenopausal age group. The commonest histology type is ductal carcinoma, that the most prevalent receptor was estrogen receptor positive, and the most common molecular subtype was Luminal A in pathology samples. Surgery is main stay of treatment and the most common surgical technique practiced in Ethiopia is modified radical mastectomy.</p><p><strong>Conclusion: </strong>Breast cancer incidence is rising, and it accounts for the major cancer burden in the country. There is a need for additional awareness-raising and health education because delayed presentation are critical problems throughout Ethiopia. For planning and monitoring cancer patterns, comprehensive demographic and clinical data from a population or facility-based registry are needed in the regions. The available treatment options are still limited in Ethiopia it needs infrastructural development.</p>","PeriodicalId":9131,"journal":{"name":"BMC Cancer","volume":null,"pages":null},"PeriodicalIF":3.4000,"publicationDate":"2024-09-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11375980/pdf/","citationCount":"0","resultStr":"{\"title\":\"Epidemiology and clinical characteristics of breast cancer in Ethiopia: a systematic review.\",\"authors\":\"Firaol Guyassa Dandena, Berhanetsehay Teklemariam Teklewold, Tadele Dana Darebo, Yisihak Debodina Suga\",\"doi\":\"10.1186/s12885-024-12822-5\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<p><strong>Background: </strong>According to GLOBOCAN 2020 Breast cancer is the most common cancer among women and the prevalence is increasing worldwide and in Ethiopia. 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引用次数: 0
摘要
背景:根据 GLOBOCAN 2020,乳腺癌是女性中最常见的癌症,其发病率在全球和埃塞俄比亚都在上升。本综述评估了在埃塞俄比亚进行的有关乳腺癌临床特征和流行病学的研究:在没有时间限制的情况下,对 PubMed、Google Scholar African Journals Online (AJOL)、Cumulative Index of Nursing and Allied Health Literature (CINAHL) 和 Hinari 进行了数据库搜索。搜索关键词包括:发病率和模式、临床表现、组织学和分子亚型以及管理。我们遵循《系统综述和元分析首选报告项目》(Preferred Reporting Items for Systematic Reviews and Meta-Analyses,PRISMA)指南来识别、搜索、提取文章并报告本系统综述。该方案已在 PROSPERO 注册,ID:CRD42023403320.Results:综述共纳入 20 项研究,参与人数达 33,369 人,其中 3 项研究以社区为基础,17 项研究以医院为基础。除两项研究外,其他研究均显示乳腺癌是埃塞俄比亚妇女最常见的癌症。最常见的症状是乳房肿块/肿块,最常受影响的一侧是右侧乳房。大多数患者在晚期才发病,且属于绝经前年龄组。最常见的组织学类型是导管癌,最常见的受体是雌激素受体阳性,病理样本中最常见的分子亚型是Luminal A。手术是主要的治疗手段,埃塞俄比亚最常用的手术技术是改良根治性乳房切除术:结论:乳腺癌发病率正在上升,是埃塞俄比亚的主要癌症负担。埃塞俄比亚全国各地都存在严重的延误就诊问题,因此有必要开展更多的提高认识活动和健康教育。为了规划和监测癌症模式,各地区需要从人口或设施登记处获得全面的人口和临床数据。埃塞俄比亚现有的治疗方案仍然有限,需要发展基础设施。
Epidemiology and clinical characteristics of breast cancer in Ethiopia: a systematic review.
Background: According to GLOBOCAN 2020 Breast cancer is the most common cancer among women and the prevalence is increasing worldwide and in Ethiopia. This review assessed studies conducted in Ethiopia on the clinical features and epidemiology of breast cancer.
Methods: Data base search conducted PubMed, Google Scholar African Journals Online (AJOL), Cumulative Index of Nursing and Allied Health Literature (CINAHL) and Hinari without time restrictions. The search keywords included; prevalence and pattern, clinical presentation, histological and molecular subtypes, and management. We followed the Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) guideline to identify, search, extract articles, and report this systematic review. The protocol was registered in PROSPERO, ID: CRD42023403320.
Results: Twenty studies were included in the review with 33,369 participants and 3 were community-based and 17 were hospital-based. In all except two reviewed studies, breast cancer is the most common cancer among women of Ethiopia. The most frequent presenting symptom was a breast lump/mass and commonly affected side was right breast. Most patients presented at a late stage and they were premenopausal age group. The commonest histology type is ductal carcinoma, that the most prevalent receptor was estrogen receptor positive, and the most common molecular subtype was Luminal A in pathology samples. Surgery is main stay of treatment and the most common surgical technique practiced in Ethiopia is modified radical mastectomy.
Conclusion: Breast cancer incidence is rising, and it accounts for the major cancer burden in the country. There is a need for additional awareness-raising and health education because delayed presentation are critical problems throughout Ethiopia. For planning and monitoring cancer patterns, comprehensive demographic and clinical data from a population or facility-based registry are needed in the regions. The available treatment options are still limited in Ethiopia it needs infrastructural development.
期刊介绍:
BMC Cancer is an open access, peer-reviewed journal that considers articles on all aspects of cancer research, including the pathophysiology, prevention, diagnosis and treatment of cancers. The journal welcomes submissions concerning molecular and cellular biology, genetics, epidemiology, and clinical trials.