供体-受体体重指数比对心脏移植受体生存结果的影响：回顾性分析研究

IF 4.6 Q2 MATERIALS SCIENCE, BIOMATERIALS ACS Applied Bio Materials Pub Date : 2024-09-04 DOI:10.1002/clc.70010

Yucheng Zhong, Changdong Zhang, Yixuan Wang, Mei Liu, Xiaoke Shang, Nianguo Dong

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摘要

研究目的本研究旨在探讨供体与受体体重指数比值对心脏移植受体生存结果的影响：方法：对 2008 年 9 月至 2021 年 6 月期间接受手术的 641 名心脏移植患者进行了回顾性分析。计算了每位患者的体重指数比（供体体重指数除以受体体重指数）。采用 Kaplan-Meier 生存分析和 Cox 比例危险回归评估生存率，并确定死亡率的危险比 (HR)：结果：BMI 比值组之间的供体年龄和供体-受体身高比存在显著差异。与 BMI 比率结论组相比，BMI 比率≥1 组的平均供体年龄更高（37.27 ± 10.54 岁）：供体-受体 BMI 比率越高，心脏移植受体的死亡风险越高。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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Impact of Donor−Recipient BMI Ratio on Survival Outcomes of Heart Transplant Recipients: A Retrospective Analysis Study

Objective

This study aimed to investigate the impact of the donor−recipient BMI ratio on the survival outcomes of heart transplant recipients.

Methods

A retrospective analysis was conducted on 641 heart transplant patients who underwent surgery between September 2008 and June 2021. The BMI ratio (donor BMI divided by recipient BMI) was calculated for each patient. Kaplan−Meier survival analysis and Cox proportional hazards regression were performed to evaluate survival rates and determine the hazard ratio (HR) for mortality.

Results

Significant differences were found in donor age and donor−recipient height ratio between the BMI ratio groups. The BMI ratio ≥ 1 group had a higher mean donor age (37.27 ± 10.54 years) compared to the BMI ratio < 1 group (34.72 ± 11.82 years, p = 0.008), and a slightly higher mean donor−recipient height ratio (1.02 ± 0.06 vs. 1.00 ± 0.05, p = 0.002). The Kaplan−Meier survival analysis indicated that the survival rate in the BMI ratio ≥ 1 group was significantly lower than in the BMI ratio < 1 group. Cox multivariate analysis, adjusted for confounding factors, revealed a HR of 1.50 (95% CI: 1.08−2.09) for mortality in patients with a BMI ratio ≥ 1. No significant differences were observed in ICU stay, postoperative hospitalization days, or total mechanical ventilation time between the groups.