Sara B A Mokhtar, Jessica Viljoen, Carla J H van der Kallen, Tos T J M Berendschot, Pieter C Dagnelie, Jeroen D Albers, Jens Soeterboek, Fabio Scarpa, Alessia Colonna, Frank C T van der Heide, Marleen M J van Greevenbroek, Hans Bosm, Abraham A Kroon, Rudy M M A Nuijts, Marlies Gijs, Jeroen Lakerveld, Rayaz A Malik, Carroll A B Webers, Coen D A Stehouwer, Annemarie Koster
{"title":"PM2.5和PM10暴露程度越高，角膜神经测量值越低：马斯特里赫特研究--一项横断面研究。","authors":"Sara B A Mokhtar, Jessica Viljoen, Carla J H van der Kallen, Tos T J M Berendschot, Pieter C Dagnelie, Jeroen D Albers, Jens Soeterboek, Fabio Scarpa, Alessia Colonna, Frank C T van der Heide, Marleen M J van Greevenbroek, Hans Bosm, Abraham A Kroon, Rudy M M A Nuijts, Marlies Gijs, Jeroen Lakerveld, Rayaz A Malik, Carroll A B Webers, Coen D A Stehouwer, Annemarie Koster","doi":"10.1186/s12940-024-01110-1","DOIUrl":null,"url":null,"abstract":"<p><strong>Background: </strong>Epidemiological and toxicological studies indicate that increased exposure to air pollutants can lead to neurodegenerative diseases. To further confirm this relationship, we evaluated the association between exposure to ambient air pollutants and corneal nerve measures as a surrogate for neurodegeneration, using corneal confocal microscopy.</p><p><strong>Methods: </strong>We used population-based observational cross-sectional data from The Maastricht Study including N = 3635 participants (mean age 59.3 years, 51.6% were women, and 19.9% had type 2 diabetes) living in the Maastricht area. Using the Geoscience and hEalth Cohort COnsortium (GECCO) data we linked the yearly average exposure levels of ambient air pollutants at home address-level [particulate matter with diameters of ≤ 2.5 µm (PM2.5), and ≤ 10.0 µm (PM10), nitrogen dioxide (NO2), and elemental carbon (EC)]. We used linear regression analysis to study the associations between Z-score for ambient air pollutants concentrations (PM<sub>2.5</sub>, PM<sub>10</sub>, NO<sub>2</sub>, and EC) and Z-score for individual corneal nerve measures (corneal nerve bifurcation density, corneal nerve density, corneal nerve length, and fractal dimension).</p><p><strong>Results: </strong>After adjustment for potential confounders (age, sex, level of education, glucose metabolism status, corneal confocal microscopy lag time, inclusion year of participants, smoking status, and alcohol consumption), higher Z-scores for PM<sub>2.5</sub> and PM<sub>10</sub> were associated with lower Z-scores for corneal nerve bifurcation density, nerve density, nerve length, and nerve fractal dimension [stβ (95% CI): PM<sub>2.5</sub> -0.10 (-0.14; -0.05), -0.04 (-0.09; 0.01), -0.11 (-0.16; -0.06), -0.20 (-0.24; -0.15); and PM<sub>10</sub> -0.08 (-0.13; -0.03), -0.04 (-0.09; 0.01), -0.08 (-0.13; -0.04), -0.17 (-0.21; -0.12)], respectively. No associations were found between NO<sub>2</sub> and EC and corneal nerve measures.</p><p><strong>Conclusions: </strong>Our population-based study demonstrated that exposure to higher levels of PM<sub>2.5</sub> and PM<sub>10</sub> are associated with higher levels of corneal neurodegeneration, estimated from lower corneal nerve measures. Our results suggest that air pollution may be a determinant for neurodegeneration assessed in the cornea and may impact the ocular surface health as well.</p>","PeriodicalId":11686,"journal":{"name":"Environmental Health","volume":null,"pages":null},"PeriodicalIF":5.3000,"publicationDate":"2024-09-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11375839/pdf/","citationCount":"0","resultStr":"{\"title\":\"Greater exposure to PM<sub>2.5</sub> and PM<sub>10</sub> was associated with lower corneal nerve measures: the Maastricht study - a cross-sectional study.\",\"authors\":\"Sara B A Mokhtar, Jessica Viljoen, Carla J H van der Kallen, Tos T J M Berendschot, Pieter C Dagnelie, Jeroen D Albers, Jens Soeterboek, Fabio Scarpa, Alessia Colonna, Frank C T van der Heide, Marleen M J van Greevenbroek, Hans Bosm, Abraham A Kroon, Rudy M M A Nuijts, Marlies Gijs, Jeroen Lakerveld, Rayaz A Malik, Carroll A B Webers, Coen D A Stehouwer, Annemarie Koster\",\"doi\":\"10.1186/s12940-024-01110-1\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<p><strong>Background: </strong>Epidemiological and toxicological studies indicate that increased exposure to air pollutants can lead to neurodegenerative diseases. To further confirm this relationship, we evaluated the association between exposure to ambient air pollutants and corneal nerve measures as a surrogate for neurodegeneration, using corneal confocal microscopy.</p><p><strong>Methods: </strong>We used population-based observational cross-sectional data from The Maastricht Study including N = 3635 participants (mean age 59.3 years, 51.6% were women, and 19.9% had type 2 diabetes) living in the Maastricht area. Using the Geoscience and hEalth Cohort COnsortium (GECCO) data we linked the yearly average exposure levels of ambient air pollutants at home address-level [particulate matter with diameters of ≤ 2.5 µm (PM2.5), and ≤ 10.0 µm (PM10), nitrogen dioxide (NO2), and elemental carbon (EC)]. We used linear regression analysis to study the associations between Z-score for ambient air pollutants concentrations (PM<sub>2.5</sub>, PM<sub>10</sub>, NO<sub>2</sub>, and EC) and Z-score for individual corneal nerve measures (corneal nerve bifurcation density, corneal nerve density, corneal nerve length, and fractal dimension).</p><p><strong>Results: </strong>After adjustment for potential confounders (age, sex, level of education, glucose metabolism status, corneal confocal microscopy lag time, inclusion year of participants, smoking status, and alcohol consumption), higher Z-scores for PM<sub>2.5</sub> and PM<sub>10</sub> were associated with lower Z-scores for corneal nerve bifurcation density, nerve density, nerve length, and nerve fractal dimension [stβ (95% CI): PM<sub>2.5</sub> -0.10 (-0.14; -0.05), -0.04 (-0.09; 0.01), -0.11 (-0.16; -0.06), -0.20 (-0.24; -0.15); and PM<sub>10</sub> -0.08 (-0.13; -0.03), -0.04 (-0.09; 0.01), -0.08 (-0.13; -0.04), -0.17 (-0.21; -0.12)], respectively. No associations were found between NO<sub>2</sub> and EC and corneal nerve measures.</p><p><strong>Conclusions: </strong>Our population-based study demonstrated that exposure to higher levels of PM<sub>2.5</sub> and PM<sub>10</sub> are associated with higher levels of corneal neurodegeneration, estimated from lower corneal nerve measures. Our results suggest that air pollution may be a determinant for neurodegeneration assessed in the cornea and may impact the ocular surface health as well.</p>\",\"PeriodicalId\":11686,\"journal\":{\"name\":\"Environmental Health\",\"volume\":null,\"pages\":null},\"PeriodicalIF\":5.3000,\"publicationDate\":\"2024-09-04\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11375839/pdf/\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Environmental Health\",\"FirstCategoryId\":\"93\",\"ListUrlMain\":\"https://doi.org/10.1186/s12940-024-01110-1\",\"RegionNum\":2,\"RegionCategory\":\"环境科学与生态学\",\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"Q1\",\"JCRName\":\"ENVIRONMENTAL SCIENCES\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Environmental Health","FirstCategoryId":"93","ListUrlMain":"https://doi.org/10.1186/s12940-024-01110-1","RegionNum":2,"RegionCategory":"环境科学与生态学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q1","JCRName":"ENVIRONMENTAL SCIENCES","Score":null,"Total":0}
Greater exposure to PM2.5 and PM10 was associated with lower corneal nerve measures: the Maastricht study - a cross-sectional study.
Background: Epidemiological and toxicological studies indicate that increased exposure to air pollutants can lead to neurodegenerative diseases. To further confirm this relationship, we evaluated the association between exposure to ambient air pollutants and corneal nerve measures as a surrogate for neurodegeneration, using corneal confocal microscopy.
Methods: We used population-based observational cross-sectional data from The Maastricht Study including N = 3635 participants (mean age 59.3 years, 51.6% were women, and 19.9% had type 2 diabetes) living in the Maastricht area. Using the Geoscience and hEalth Cohort COnsortium (GECCO) data we linked the yearly average exposure levels of ambient air pollutants at home address-level [particulate matter with diameters of ≤ 2.5 µm (PM2.5), and ≤ 10.0 µm (PM10), nitrogen dioxide (NO2), and elemental carbon (EC)]. We used linear regression analysis to study the associations between Z-score for ambient air pollutants concentrations (PM2.5, PM10, NO2, and EC) and Z-score for individual corneal nerve measures (corneal nerve bifurcation density, corneal nerve density, corneal nerve length, and fractal dimension).
Results: After adjustment for potential confounders (age, sex, level of education, glucose metabolism status, corneal confocal microscopy lag time, inclusion year of participants, smoking status, and alcohol consumption), higher Z-scores for PM2.5 and PM10 were associated with lower Z-scores for corneal nerve bifurcation density, nerve density, nerve length, and nerve fractal dimension [stβ (95% CI): PM2.5 -0.10 (-0.14; -0.05), -0.04 (-0.09; 0.01), -0.11 (-0.16; -0.06), -0.20 (-0.24; -0.15); and PM10 -0.08 (-0.13; -0.03), -0.04 (-0.09; 0.01), -0.08 (-0.13; -0.04), -0.17 (-0.21; -0.12)], respectively. No associations were found between NO2 and EC and corneal nerve measures.
Conclusions: Our population-based study demonstrated that exposure to higher levels of PM2.5 and PM10 are associated with higher levels of corneal neurodegeneration, estimated from lower corneal nerve measures. Our results suggest that air pollution may be a determinant for neurodegeneration assessed in the cornea and may impact the ocular surface health as well.
期刊介绍：
Environmental Health publishes manuscripts on all aspects of environmental and occupational medicine and related studies in toxicology and epidemiology.
Environmental Health is aimed at scientists and practitioners in all areas of environmental science where human health and well-being are involved, either directly or indirectly. Environmental Health is a public health journal serving the public health community and scientists working on matters of public health interest and importance pertaining to the environment.
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