RNA m 6A 作者的结构和机制。

IF 3.3 2区生物学 Q2 BIOCHEMISTRY & MOLECULAR BIOLOGY Acta biochimica et biophysica Sinica Pub Date : 2024-09-06 DOI:10.3724/abbs.2024152

Ting Deng, Jinbiao Ma

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引用次数: 0

摘要

N 6-甲基腺苷（m 6A）是真核生物 mRNA 中最常见的表观遗传修饰，通过影响 mRNA 代谢的多个方面，在调节基因表达方面发挥着至关重要的作用。mRNA 和长非编码 RNA 的 m 6A 作者由催化亚基 m 6A-METTL 复合物（MTC）（包括 METTL3/METTL14）和调控亚基 m 6A-METTL 相关复合物（MACOM）（包括 HAKAI、WTAP、VIRMA、ZC3H13 和 RBM15/15B）组成。在这篇综述中，我们将重点介绍最近在了解 m 6A 写子的结构和功能特性方面取得的进展，以及它们识别 RNA 底物并进行选择性 m 6A 修饰的可能机制。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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Structures and mechanisms of the RNA m ⁶A writer.

N ⁶-methyladenosine (m ⁶A) is the most prevalent epigenetic modification found in eukaryotic mRNAs and plays a crucial role in regulating gene expression by influencing numerous aspects of mRNA metabolism. The m ⁶A writer for mRNAs and long non-coding RNAs consists of the catalytic subunit m ⁶A-METTL complex (MTC) (including METTL3/METTL14) and the regulatory subunit m ⁶A-METTL-associated complex (MACOM) (including HAKAI, WTAP, VIRMA, ZC3H13, and RBM15/15B). In this review, we focus on recent advances in our understanding of the structural and functional properties of m ⁶A writers and the possible mechanism by which they recognize RNA substrates and perform selective m ⁶A modifications.

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来源期刊

Acta biochimica et biophysica Sinica 生物-生化与分子生物学

CiteScore

5.00

自引率

5.40%

发文量

170

审稿时长

3 months

期刊介绍： Acta Biochimica et Biophysica Sinica (ABBS) is an internationally peer-reviewed journal sponsored by the Shanghai Institute of Biochemistry and Cell Biology (CAS). ABBS aims to publish original research articles and review articles in diverse fields of biochemical research including Protein Science, Nucleic Acids, Molecular Biology, Cell Biology, Biophysics, Immunology, and Signal Transduction, etc.