评估新诊断出的 1 型糖尿病患儿的脉络膜结构。

Beyoglu Eye Journal Pub Date : 2024-09-01 eCollection Date: 2024-01-01 DOI:10.14744/bej.2024.36036
Serdar Bilici, Tuba Gultekin Erol, Meliha Esra Bilici, Silay Canturk Ugurbas, Suat Hayri Ugurbas
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引用次数: 0

摘要

研究目的本研究旨在评估新确诊的 1 型糖尿病(T1DM)患儿的眼底脉络膜厚度(SFCT)和脉络膜血管指数(CVI):这项横断面研究共纳入了 80 名儿童(40 名 T1DM 患儿和 40 名健康对照组儿童)。对所有参与者的增强深度成像光学相干断层扫描(EDI-OCT)图像进行了分析。研究人员从 EDI-OCT 图像中获得了 SFCT、脉络膜总面积(TCA)、管腔面积(LA)、基质面积(SA)和 CVI 测量值,并对各组进行了比较。研究了 HbA1c、空腹血浆葡萄糖和轴长测量对脉络膜测量的影响:结果:TCA(0.84 [0.57-1.26] vs. 0.88 [0.65-1.16] mm2,P=0.745)、LA(0.55 [0.41-0.79] vs. 0.59 [0.43-0.74] mm2,p=0.745)、SA(0.27 [0.15-0.47] vs. 0.28 [0.15-0.47] mm2,p=0.935)和CVI(68.03 [66.5-70.5] vs. 67.75 [66.2-69.5] %,p=0.794)。然而,与对照组相比,T1DM 患者的 SFCT 更薄(分别为 309.0 [327-489] 和 398.5 [219-491],P=0.794):与健康儿童相比,新诊断为 T1DM 的儿童的 SCFT 较薄,但两组间的 CVI 并无明显差异。应通过长期随访来确认 DM 持续时间对 CVI 的影响。
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Evaluation of Choroidal Structures in Children with Newly Diagnosed Type-1 Diabetes Mellitus.

Objectives: The objective of this study was to evaluate the subfoveal choroidal thickness (SFCT) and choroidal vascularity index (CVI) in children with newly diagnosed type 1 diabetes mellitus (T1DM).

Methods: A total of 80 children (40 with T1DM and 40 healthy controls) were included in this cross-sectional study. Enhanced depth imaging optical coherence tomography (EDI-OCT) images of all participants were analyzed. The SFCT, total choroidal area (TCA), luminal area (LA), stromal area (SA), and CVI measurements were obtained from EDI-OCT images and compared between groups. The effects of HbA1c, fasting plasma glucose, and axial length measurements on choroidal measurements were investigated.

Results: There was no significant difference between the groups according to TCA (0.84 [0.57-1.26] vs. 0.88 [0.65-1.16] mm2, p=0.745), LA (0.55 [0.41-0.79] vs. 0.59 [0.43-0.74] mm2, p=0.745), SA (0.27 [0.15-0.47] vs. 0.28 [0.15-0.47] mm2, p=0.935), and CVI (68.03 [66.5-70.5] vs. 67.75 [66.2-69.5] %, p=0.794), respectively. However, T1DM patients had thinner SFCT compared to control subjects (309.0 [327-489] and 398.5 [219-491], p<0.044). No correlation was found between HbA1c, fasting plasma glucose, axial length measurements, and SFCT, TCA, LA, SA, or CVI.

Conclusion: Children with newly diagnosed T1DM have thinner SCFT in comparison to healthy children, however, no significant difference in CVI was observed between the groups. Long-term follow-up should be used to confirm the impact of the DM duration on CVI.

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