评估多发性硬化症患者毛细血管周围脉络膜厚度、视网膜神经纤维层和视神经头参数。

Beyoglu Eye Journal Pub Date : 2024-09-01 eCollection Date: 2024-01-01 DOI:10.14744/bej.2024.22590
Murat Garli, Sevda Aydin Kurna, Eren Gozke, Nihan Parasiz Yukselen
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引用次数: 0

摘要

研究目的本研究的目的是评估多发性硬化症(MS)患者与健康人相比的毛细血管周围脉络膜厚度(PPCT)、视网膜神经纤维层(RNFL)和视神经头(ONH)参数:这项横断面研究纳入了 64 名患者的 128 只眼睛。对 41 名多发性硬化症患者的 82 只眼睛和 23 名健康受试者的 46 只眼睛进行了检查。使用光谱域光学相干断层扫描(OCT)测量 PPCT 和 RNFL。PPCT 在视盘周围四个象限测量,距离 ONH 边缘和视网膜色素上皮起始处分别为 1 毫米(PPCT-1)和 2 毫米(PPCT-2)。用海德堡视网膜断层扫描(HRT-3)测量视网膜上皮参数。记录了病程、发作次数、多发性硬化症亚型和扩展残疾状态量表(EDSS)评分:结果:与健康人相比,多发性硬化症患者的 RNFL 测量值以及 PPCT-1 和 PPCT-2 平均值明显较低。两组患者中,PPCT-1和PPCT-2分别在颞象限最厚,其次是上象限、鼻象限和下象限。在评估视网膜上皮参数时,与健康人相比,多发性硬化症患者的杯状/盘状面积比、杯状面积和杯状体积值明显较高,而视缘体积和视缘面积值则明显较低(p结论:与健康受试者相比,多发性硬化症患者的 RNFL 厚度、PPCT 和 ONH 参数有明显变化。用OCT评估RNFL和PPCT以及用HRT-3评估ONH可能对多发性硬化症患者的随访有用。
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Evaluation of Peripapillary Choroidal Thickness, Retinal Nerve Fiber Layer, and Optic Nerve Head Parameters in Patients with Multiple Sclerosis.

Objectives: The objectives of the study are to assess the peripapillary choroidal thickness (PPCT), retinal nerve fiber layer (RNFL), and optic nerve head (ONH) parameters in multiple sclerosis (MS) patients compared to healthy subjects.

Methods: One hundred and twenty-eight eyes from 64 patients were included in this cross-sectional study. Eighty-two eyes of 41 MS patients and 46 eyes of 23 healthy subjects were examined. PPCT and RNFL were measured using spectral-domain optical coherence tomography (OCT). PPCT was measured from the four quadrants around the optic disc at a distance of 1 mm (PPCT-1) and 2 mm (PPCT-2) from the edge of the ONH and the beginning of the retinal pigment epithelium. ONH parameters were measured with Heidelberg retinal tomography (HRT-3). Disease duration, the number of episodes, MS subtypes, and Expanded Disability Status Scale (EDSS) scores were recorded.

Results: The RNFL measurements and the mean PPCT-1 and PPCT-2 were significantly lower in MS patients compared to healthy individuals. PPCT-1 and PPCT-2 were measured as the thickest in the temporal quadrant, followed by the superior, nasal, and inferior quadrants, respectively, in both groups. When the ONH parameters were evaluated, cup/disc area ratio, cup area, and cup volume values were significantly higher, whereas optic rim volume and rim area values were significantly lower in MS patients compared to healthy subjects (p<0.05). We observed significant changes in RNFL and ONH parameters of MS patients in parallel with disease severity determined by EDSS scores and the presence of optic neuritis.

Conclusion: There were significant changes in RNFL thickness, PPCT, and ONH parameters when MS patients were compared with healthy subjects. Assessment of RNFL and PPCT with OCT and ONH with HRT-3 may be useful in the follow-up of MS patients.

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审稿时长
16 weeks
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