给小鼠服用西酞普兰并摄入高碳水化合物和高胆固醇饮食后,小鼠的血脂状况、葡萄糖代谢和瘦素水平会受到破坏。

IF 2.9 4区 医学 Q2 PHARMACOLOGY & PHARMACY Pharmacology Pub Date : 2024-09-05 DOI:10.1159/000541229
Tomáš Hammer, Hana Kotolová, Jiří Procházka, Michal Karpíšek
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引用次数: 0

摘要

导言 抑郁症治疗与对能量代谢的负面影响有关,这可归因于多种因素,包括代谢紊乱中常见的持续炎症过程。患者选择不健康的生活方式以及抗抑郁药物对体重、脂质和葡萄糖代谢的影响也是造成这些代谢副作用的原因。尽管抗抑郁药的使用不像其他精神药物那样明显,但其使用量的增加引起了人们对其对公众健康潜在影响的担忧。本研究旨在评估抗抑郁药西酞普兰及其与特殊饮食长期结合对小鼠代谢参数的短期和长期影响。方法 将动物随机分为 5 组--对照组、对照组+特殊饮食组、西酞普兰组(10 毫克/千克,35 天)、西酞普兰+特殊饮食组(10 毫克/千克,35 天)和西酞普兰组(10 毫克/千克,7 天)。在所述给药时间后,对动物进行麻醉,采集血液、脂肪和肝组织。用分光光度法分析脂质代谢的生化指标(总胆固醇、高密度脂蛋白胆固醇、低密度脂蛋白胆固醇、甘油三酯)和葡萄糖,用酶联免疫吸附法评估相关的脂肪因子和细胞因子。结果 在服用西酞普兰一周后,我们观察到血脂异常,甚至在五周实验结束时血脂异常仍然存在。此外,在服用西酞普兰五周后,我们观察到体重增加明显减少,瘦素水平也有所下降。五周后,由于特殊饮食,我们观察到脂质代谢发生了变化,脂肪因子瘦素和 PAI-1 水平升高。结论 我们的研究表明,无论是短期(1 周)还是长期(5 周),西酞普兰和饮食对小鼠新陈代谢的影响都是显著的。
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Disruption of Lipid Profile, Glucose Metabolism, and Leptin Levels following Citalopram Administration and High-Carbohydrate and High-Cholesterol Diet in Mice.

Introduction: Depression therapy has been linked to negative effects on energy metabolism, which can be attributed to various factors, including an ongoing inflammatory process commonly seen in metabolic disorders. Unhealthy lifestyle choices of patients and the impact of antidepressants on body weight and lipid and glucose metabolism also contribute to these metabolic side effects. Although not as pronounced as other psychopharmaceuticals, the increasing use of antidepressants raises concerns about their potential impact on public health. The study aimed to evaluate the short- and long-term effects of the antidepressant citalopram and its long-term combination with a special diet on metabolic parameters in mice.

Methods: Animals were randomly divided into 5 groups - control, control + special diet, citalopram (10 mg/kg for 35 days), citalopram + special diet (10 mg/kg for 35 days), and citalopram (10 mg/kg for 7 days). After a described time of administration, animals were anesthetized, blood and fat and liver tissues were collected. Biochemical parameters of lipid metabolism (total cholesterol, HDL cholesterol, LDL cholesterol, triglycerides) and glucose were analyzed using spectrophotometry and relevant adipokines and cytokines were evaluated by ELISA.

Results: After a week of application of citalopram, we observed dyslipidemia that persisted even at the end of the 5-week experiment. Furthermore, after 5 weeks of citalopram administration, we observed a significant decrease in body weight gain and decreased leptin levels. Changes in lipid metabolism, higher levels of adipokines leptin and PAI-1 were observed due to the special diet after 5 weeks.

Conclusions: Our research suggests that the effects of citalopram and a diet on the metabolism of mice can be significant, both in the short term (1 week) and in the long term (5 weeks).

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来源期刊
Pharmacology
Pharmacology 医学-药学
CiteScore
5.60
自引率
0.00%
发文量
52
审稿时长
6-12 weeks
期刊介绍: ''Pharmacology'' is an international forum to present and discuss current perspectives in drug research. The journal communicates research in basic and clinical pharmacology and related fields. It covers biochemical pharmacology, molecular pharmacology, immunopharmacology, drug metabolism, pharmacogenetics, analytical toxicology, neuropsychopharmacology, pharmacokinetics and clinical pharmacology. In addition to original papers and short communications of investigative findings and pharmacological profiles the journal contains reviews, comments and perspective notes; research communications of novel therapeutic agents are encouraged.
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