病程长达 18 年的 90 岁老人的 IgG4 相关疾病:病例报告。

IF 1.1 4区 医学 Q4 IMMUNOLOGY Iranian Journal of Immunology Pub Date : 2024-09-08 DOI:10.22034/iji.2024.103289.2828
Qitao Ren, Ying Jin, Guangxin Zhou, Qiaoxiang Yin, Ping Liu, Yanjie Cao, Yongmin Bi
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引用次数: 0

摘要

IgG4 相关疾病(IgG4-RD)是一种由分泌 IgG4 的浆细胞浸润组织引起的多器官炎症性免疫介导疾病。这种疾病通常影响老年男性。根据 2019 年 ACR/EULAR 新分类标准,一名 90 岁的中国男性被诊断为 IgG4-RD,因为他有多个器官受累。在接受糖皮质激素、来氟米特和γ-球蛋白治疗后,患者的临床症状明显改善,证实了诊断的准确性。患者有 18 年的病史,由于诊断和治疗延误,病情逐渐恶化。虽然通过适当的药物治疗缓解了相关症状,但整个治疗过程却遇到了挑战。由于患者肾上腺皮质功能相对缺乏,在激素减少过程中出现了恶心、疲惫、食欲不振等症状。因此,及时干预对于解决激素治疗的副作用尤为重要。
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IgG4-Related Disease in a 90-Year-Old Man with an 18-Year Disease Course: A Case Report.

IgG4-related disease (IgG4-RD) is a multi-organ inflammatory immune-mediated illness caused by IgG4-secreting plasma cells infiltrating the tissue. This condition usually affects elderly men. A 90-year-old Chinese male was diagnosed with IgG4-RD based on the new 2019 ACR/EULAR classification criteria, as he had multiple organ involvement. After receiving treatment with glucocorticoids, leflunomide, and gamma-globulin, the patient's clinical symptoms significantly improved, confirming the accuracy of the diagnosis. The patient had an 18-year medical history during which the disease progressively worsened due to delayed diagnosis and treatment. Although the relevant symptoms were alleviated with appropriate medication, the overall treatment process encountered challenges. Due to the patient's relative lack of adrenocortical function, he experienced symptoms such as nausea, exhaustion, and loss of appetite during the hormone reduction process. Therefore, timely intervention is especially crucial to address the side effects of hormone therapy.

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来源期刊
Iranian Journal of Immunology
Iranian Journal of Immunology Medicine-Immunology and Allergy
CiteScore
1.60
自引率
0.00%
发文量
50
审稿时长
12 weeks
期刊介绍: The Iranian Journal of Immunology (I.J.I) is an internationally disseminated peer-reviewed publication and publishes a broad range of experimental and theoretical studies concerned with all aspects of immunology.
期刊最新文献
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