Ecnomotopic olfactory receptors in metabolic regulation

Olfactory receptors are seven-transmembrane G-protein-coupled receptors on the cell surface. Over the past few decades, evidence has been mounting that olfactory receptors are not unique to the nose and that their ectopic existence plays an integral role in extranasal diseases. Coupled with the discovery of many natural or synthetic odor-compound ligands, new roles of ecnomotopic olfactory receptors regulating blood glucose, obesity, blood pressure, and other metabolism-related diseases are emerging. Many well-known scientific journals have called for attention to extranasal functions of ecnomotopic olfactory receptors. Thus, the prospect of ecnomotopic olfactory receptors in drug target research has been greatly underestimated. Here, we have provided an overview for the role of ecnomotopic olfactory receptors in metabolic diseases, focusing on their effects on various metabolic tissues, and discussed the possible molecular biological and pathophysiological mechanisms, which provide the basis for drug development and clinical application targeting the function of ecnomotopic olfactory receptors via literature machine learning and screening.