{"title":"氧化铝载钯作为高活性异相催化剂,通过 CH 键活化反应直接芳基化 6-取代咪唑并[2,1-b]噻二唑","authors":"","doi":"10.1016/j.tetlet.2024.155286","DOIUrl":null,"url":null,"abstract":"<div><p>Fast, atom-economical, phosphine-free, and eco-friendly microwave-irradiated reactions permitting the “green synthesis” of 5,6-disubstituted imidazo[2,1-<em>b</em>]thiadiazole derivatives using heterogeneous palladium catalyst in triethylammonium 2-(1,1-dioxido-3-oxobenzo[<em>d</em>]isothiazol-2(3H)-yl)acetate ([Et<sub>3</sub>NH][Sac-CH<sub>3</sub>CO<sub>2</sub>]) ionic liquid <em>via</em> C<img>H bond activation reaction of 6-substituted imidazo[2,1-<em>b</em>]thiadiazole derivatives, are reported. This method provides a straightforward route to a wide variety of substituted imidazo[2,1-<em>b</em>]thiadiazoles and has the advantages of reusability of the heterogeneous catalyst, simple methodology, high yields, and easy work-up.</p></div>","PeriodicalId":438,"journal":{"name":"Tetrahedron Letters","volume":null,"pages":null},"PeriodicalIF":1.5000,"publicationDate":"2024-08-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":"{\"title\":\"Palladium supported on alumina as a highly active heterogeneous catalyst for direct arylation of 6-substituted imidazo[2,1-b]thiadiazole via CH bond activation reaction\",\"authors\":\"\",\"doi\":\"10.1016/j.tetlet.2024.155286\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<div><p>Fast, atom-economical, phosphine-free, and eco-friendly microwave-irradiated reactions permitting the “green synthesis” of 5,6-disubstituted imidazo[2,1-<em>b</em>]thiadiazole derivatives using heterogeneous palladium catalyst in triethylammonium 2-(1,1-dioxido-3-oxobenzo[<em>d</em>]isothiazol-2(3H)-yl)acetate ([Et<sub>3</sub>NH][Sac-CH<sub>3</sub>CO<sub>2</sub>]) ionic liquid <em>via</em> C<img>H bond activation reaction of 6-substituted imidazo[2,1-<em>b</em>]thiadiazole derivatives, are reported. This method provides a straightforward route to a wide variety of substituted imidazo[2,1-<em>b</em>]thiadiazoles and has the advantages of reusability of the heterogeneous catalyst, simple methodology, high yields, and easy work-up.</p></div>\",\"PeriodicalId\":438,\"journal\":{\"name\":\"Tetrahedron Letters\",\"volume\":null,\"pages\":null},\"PeriodicalIF\":1.5000,\"publicationDate\":\"2024-08-31\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Tetrahedron Letters\",\"FirstCategoryId\":\"92\",\"ListUrlMain\":\"https://www.sciencedirect.com/science/article/pii/S0040403924003812\",\"RegionNum\":4,\"RegionCategory\":\"化学\",\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"Q3\",\"JCRName\":\"CHEMISTRY, ORGANIC\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Tetrahedron Letters","FirstCategoryId":"92","ListUrlMain":"https://www.sciencedirect.com/science/article/pii/S0040403924003812","RegionNum":4,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q3","JCRName":"CHEMISTRY, ORGANIC","Score":null,"Total":0}
Palladium supported on alumina as a highly active heterogeneous catalyst for direct arylation of 6-substituted imidazo[2,1-b]thiadiazole via CH bond activation reaction
Fast, atom-economical, phosphine-free, and eco-friendly microwave-irradiated reactions permitting the “green synthesis” of 5,6-disubstituted imidazo[2,1-b]thiadiazole derivatives using heterogeneous palladium catalyst in triethylammonium 2-(1,1-dioxido-3-oxobenzo[d]isothiazol-2(3H)-yl)acetate ([Et3NH][Sac-CH3CO2]) ionic liquid via CH bond activation reaction of 6-substituted imidazo[2,1-b]thiadiazole derivatives, are reported. This method provides a straightforward route to a wide variety of substituted imidazo[2,1-b]thiadiazoles and has the advantages of reusability of the heterogeneous catalyst, simple methodology, high yields, and easy work-up.
期刊介绍:
Tetrahedron Letters provides maximum dissemination of outstanding developments in organic chemistry. The journal is published weekly and covers developments in techniques, structures, methods and conclusions in experimental and theoretical organic chemistry. Rapid publication of timely and significant research results enables researchers from all over the world to transmit quickly their new contributions to large, international audiences.