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引用次数: 0
摘要
疫苗是目前最有效的干预措施，可提供针对目标病原体的保护性免疫。2019 年冠状病毒疾病大流行的出现，促使基于 mRNA 的脂质纳米颗粒封装疫苗的快速开发和部署。虽然这些疫苗已显示出显著的免疫原性，但人们仍然担心它们能否对不断演变的严重急性呼吸系统综合征冠状病毒 2（SARS-CoV-2）变种产生持久的保护性免疫。本综述重点探讨接种 SARS-CoV-2 mRNA 疫苗诱导的人类 B 细胞反应，特别强调生殖中心反应在形成持久保护性免疫力中的关键作用。此外，我们还探讨了免疫印记的观察结果，以及在接种基于关注的变异株加强免疫后回忆原有免疫力的动态变化。本综述中的观点有助于全面了解人类 B 细胞对 mRNA 疫苗接种的反应，从而完善疫苗接种策略，针对不断演变的冠状病毒变种提供最佳和持续的保护。
Germinal Center Response to mRNA Vaccination and Impact of Immunological Imprinting on Subsequent Vaccination.
Vaccines are the most effective intervention currently available, offering protective immunity against targeted pathogens. The emergence of the coronavirus disease 2019 pandemic has prompted rapid development and deployment of lipid nanoparticle encapsulated, mRNA-based vaccines. While these vaccines have demonstrated remarkable immunogenicity, concerns persist regarding their ability to confer durable protective immunity to continuously evolving severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) variants. This review focuses on human B cell responses induced by SARS-CoV-2 mRNA vaccination, with particular emphasis on the crucial role of germinal center reactions in shaping enduring protective immunity. Additionally, we explored observations of immunological imprinting and dynamics of recalled pre-existing immunity following variants of concern-based booster vaccination. Insights from this review contribute to comprehensive understanding B cell responses to mRNA vaccination in humans, thereby refining vaccination strategies for optimal and sustained protection against evolving coronavirus variants.
期刊介绍：
Immune Network publishes novel findings in basic and clinical immunology and aims to provide a medium through which researchers in various fields of immunology can share and connect. The journal focuses on advances and insights into the regulation of the immune system and the immunological mechanisms of various diseases. Research that provides integrated insights into translational immunology is given preference for publication. All submissions are evaluated based on originality, quality, clarity, and brevity
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