低剂量放疗通过诱导淋巴细胞和纤维母细胞样滑膜细胞凋亡减轻实验性自身免疫性关节炎的病情

IF 4.3 4区 医学 Q2 IMMUNOLOGY Immune Network Pub Date : 2024-08-12 eCollection Date: 2024-08-01 DOI:10.4110/in.2024.24.e32
Bo-Gyu Kim, Hoon Sik Choi, Yong-Ho Choe, Hyun Min Jeon, Ji Yeon Heo, Yun-Hong Cheon, Ki Mun Kang, Sang-Il Lee, Bae Kwon Jeong, Mingyo Kim
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引用次数: 0

摘要

低剂量放射治疗(LDRT)已被视为多种炎症性疾病的治疗方法之一,但其在类风湿性关节炎(RA)中的应用尚属空白。本研究旨在阐明以 LDRT 为基础的 RA 治疗机制,并将其标准化。LDRT减少了胶原诱导性关节炎和K/BxN模型引流淋巴结中免疫细胞的总数,但增加了凋亡的CD4+ T细胞和B220+ B细胞。此外,它还能明显减轻各种病理表现的严重程度,包括骨破坏、软骨侵蚀和后肢踝关节肿胀。LDRT后,在人类RA患者的PBMCs中,CD4+ T细胞和CD19+ B细胞凋亡的比例明显增加。LDRT 对成纤维细胞样滑膜细胞也有类似作用。总之,我们报告了 LDRT 可诱导免疫细胞和纤维母细胞样滑膜细胞凋亡,从而减轻关节炎。
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Low-Dose Radiotherapy Attenuates Experimental Autoimmune Arthritis by Inducing Apoptosis of Lymphocytes and Fibroblast-Like Synoviocytes.

Low-dose radiotherapy (LDRT) has been explored as a treatment option for various inflammatory diseases; however, its application in the context of rheumatoid arthritis (RA) is lacking. This study aimed to elucidate the mechanism underlying LDRT-based treatment for RA and standardize it. LDRT reduced the total numbers of immune cells, but increased the apoptotic CD4+ T and B220+ B cells, in the draining lymph nodes of collagen induced arthritis and K/BxN models. In addition, it significantly reduced the severity of various pathological manifestations, including bone destruction, cartilage erosion, and swelling of hind limb ankle. Post-LDRT, the proportion of apoptotic CD4+ T and CD19+ B cells increased significantly in the PBMCs derived from human patients with RA. LDRT showed a similar effect in fibroblast-like synoviocytes as well. In conclusion, we report that LDRT induces apoptosis in immune cells and fibro-blast-like synoviocytes, contributing to attenuation of arthritis.

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来源期刊
Immune Network
Immune Network Immunology and Microbiology-Immunology
CiteScore
2.90
自引率
3.30%
发文量
36
期刊介绍: Immune Network publishes novel findings in basic and clinical immunology and aims to provide a medium through which researchers in various fields of immunology can share and connect. The journal focuses on advances and insights into the regulation of the immune system and the immunological mechanisms of various diseases. Research that provides integrated insights into translational immunology is given preference for publication. All submissions are evaluated based on originality, quality, clarity, and brevity
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