mTOR 信号:在乙型肝炎病毒感染和肝细胞癌中的作用

IF 8.2 2区 生物学 Q1 BIOCHEMISTRY & MOLECULAR BIOLOGY International Journal of Biological Sciences Pub Date : 2024-08-01 eCollection Date: 2024-01-01 DOI:10.7150/ijbs.95894
Ling Mei, Huizhen Sun, Ying Yan, Huimin Ji, Qian Su, Le Chang, Lunan Wang
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引用次数: 0

摘要

目前,慢性乙型肝炎病毒感染仍是世界上最严重的公共卫生问题之一。尽管目前的治疗策略能有效控制感染并延缓疾病进程,但由于无法清除cccDNA池,大多数患者要实现慢性乙型肝炎的功能性治愈仍面临巨大挑战。哺乳动物雷帕霉素靶蛋白(mTOR)整合营养、能量、生长因子和其他细胞外信号,参与基因转录、蛋白质翻译、核糖体合成和其他生物过程。此外,mTOR 还在细胞生长、凋亡、自噬和新陈代谢中发挥着极其重要的作用。越来越多的证据表明,HBV 感染可激活 mTOR 通路,这表明 HBV 利用或劫持了 mTOR 通路来促进自身的复制。因此,mTOR 信号通路可能是控制 HBV 感染的关键靶点。然而,中心细胞因子 mTOR 在 HBV 感染发病机制中的作用尚未得到系统研究。本综述系统地总结了 mTOR 在 HBV 生命周期中的作用及其对 HBV 感染临床进展的影响。
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mTOR Signaling: Roles in Hepatitis B Virus Infection and Hepatocellular Carcinoma.

Currently, chronic hepatitis B virus infection is still one of the most serious public health problems in the world. Though current strategies are effective in controlling infection and slowing down the disease process, it remains a big challenge to achieve a functional cure for chronic hepatitis B in a majority of patients due to the inability to clear the cccDNA pool. The mammalian target of rapamycin (mTOR) integrates nutrition, energy, growth factors, and other extracellular signals, participating in gene transcription, protein translation, ribosome synthesis, and other biological processes. Additionally, mTOR plays an extremely important role in cell growth, apoptosis, autophagy, and metabolism. More and more evidence show that HBV infection can activate the mTOR pathway, suggesting that HBV uses or hijacks the mTOR pathway to facilitate its own replication. Therefore, mTOR signaling pathway may be a key target for controlling HBV infection. However, the role of the central cytokine mTOR in the pathogenesis of HBV infection has not yet been systematically addressed. Notably, mTOR is commonly activated in hepatocellular carcinoma, which can progress from chronic hepatitis B. This review systematically summarizes the role of mTOR in the life cycle of HBV and its impact on the clinical progression of HBV infection.

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来源期刊
International Journal of Biological Sciences
International Journal of Biological Sciences 生物-生化与分子生物学
CiteScore
16.90
自引率
1.10%
发文量
413
审稿时长
1 months
期刊介绍: The International Journal of Biological Sciences is a peer-reviewed, open-access scientific journal published by Ivyspring International Publisher. It dedicates itself to publishing original articles, reviews, and short research communications across all domains of biological sciences.
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