甲状腺功能与子痫前期:双样本双向孟德尔随机研究。

IF 3.3 2区 医学 Q1 PERIPHERAL VASCULAR DISEASE Journal of Hypertension Pub Date : 2024-12-01 Epub Date: 2024-06-12 DOI:10.1097/HJH.0000000000003791
Chu Li, Jingjing Sheng, Yawei Zhang, Qiaofei Lyu, Liwei Yang, Zixing Zhong
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引用次数: 0

摘要

背景:甲状腺功能障碍与妊娠期子痫前期(PE)有关,但观察结果相互矛盾。我们的研究旨在通过两个大型遗传汇总数据,研究甲状腺功能对子痫前期的遗传预测效应与子痫前期的遗传预测效应之间的因果关系和方向:我们使用两个主要来自欧洲的队列:ThyroidOmics Consortium 和 FinnGen Biobank 的全基因组关联研究(GWAS)摘要数据,进行了一项双向样本孟德尔随机化(MR)研究。我们采用随机效应逆方差加权(IVW)作为主要分析方法。MR-Egger和加权中位数用于敏感性分析。统计分析使用 R 程序(4.3.0 版)和双样本软件包(0.5.6 版)进行:结果表明,遗传预测的甲状腺功能亢进与妊娠期PE有因果关系[β = 0.06,95% 置信区间(CI):1.01-1.12;P = 0.02],遗传预测的甲状腺功能减退与妊娠期PE也有因果关系(β = 0.11,95% CI:1.03-1.21;P = 0.01)。敏感性分析进一步证实了这些影响。相反,在反向 MR 结果中,子痫前期与甲状腺功能障碍的风险无关:促甲状腺激素(β = 0.00,P = 0.92)、游离甲状腺素(FT4)(β = -0.01,P = 0.56)、三碘甲状腺原氨酸(FT3)(β = -0.00,P = 0.72)、FT3/FT4(β = -0.01,P = 0.38)、甲状腺过氧化物酶抗体(β = -0.01,P = 0.64)、甲状腺功能亢进(β = -0.11,P = 0.29)和甲状腺功能减退(β = 0.04,P = 0.12):我们的研究表明,甲状腺功能亢进/低下对子痫前期有因果关系,而PE与甲状腺功能障碍没有因果关系。
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Thyroid function and preeclampsia: a two-sample bidirectional Mendelian randomization study.

Background: Thyroid dysfunction has been associated with preeclampsia (PE) during pregnancy, but the observational results are conflicting. Our study aims to investigate the causal association and direction between genetically predicted effects of thyroid function on PE and vice versa via two large summary genetic data.

Methods: We conducted a two-sample bidirectional Mendelian randomization (MR) study using genome-wide association studies (GWAS) summary data from two primarily European cohorts: the ThyroidOmics Consortium and the FinnGen Biobank. We applied the random effects inverse variance weighted (IVW) as our main analysis. MR-Egger and weighted median were used for sensitivity analysis. Statistical analysis was performed using the R program (version 4.3.0) with the two-sample package (version 0.5.6).

Results: The results suggest that genetically predicted hyperthyroidism is causally associated with PE during pregnancy [ β  = 0.06, 95% confidence interval (CI): 1.01-1.12; P  = 0.02], and genetically predicted hypothyroidism is also causally associated with PE during pregnancy ( β  = 0.11, 95% CI: 1.03-1.21; P  = 0.01). These effects were further confirmed with sensitivity analysis. Conversely, preeclampsia is not associated with the risk of thyroid dysfunction in the reverse MR results: thyroid-stimulating hormone ( β  = 0.00, P  = 0.92), free thyroxine (FT4) ( β  = -0.01, P  = 0.56), triiodothyronine (FT3) ( β  = -0.00, P  = 0.72), FT3/FT4 ( β  = -0.01, P  = 0.38), thyroid peroxidase antibodies ( β  = -0.01, P  = 0.64), hyperthyroidism ( β  = -0.11, P  = 0.29) and hypothyroidism ( β  = 0.04, P  = 0.12).

Conclusion: Our study suggests that hyper-/hypo-thyroidism causally affected preeclampsia, while PE is not causally associated with thyroid dysfunctions.

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来源期刊
Journal of Hypertension
Journal of Hypertension 医学-外周血管病
CiteScore
7.90
自引率
6.10%
发文量
1389
审稿时长
3 months
期刊介绍: The Journal of Hypertension publishes papers reporting original clinical and experimental research which are of a high standard and which contribute to the advancement of knowledge in the field of hypertension. The Journal publishes full papers, reviews or editorials (normally by invitation), and correspondence.
期刊最新文献
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