作为多发性硬化症生物标志物的端粒长度。

IF 4.8 2区 医学 Q1 CLINICAL NEUROLOGY Multiple Sclerosis Journal Pub Date : 2024-09-01 Epub Date: 2024-09-09 DOI:10.1177/13524585241273054
Maria Agustina Piedrabuena, Jorge Correale, Mauricio Franco Farez, Sofia Rodríguez Murúa, Carlos Martínez Canyazo, Marcela Fiol, Mariano Marrodan, Maria Celica Ysrraelit
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引用次数: 0

摘要

背景:白细胞端粒长度(LTL)会随着年龄的增长而缩短,可能与多发性硬化症(MS)有关:我们假设,按时间顺序排列的年轻多发性硬化症患者(pwMS)的端粒长度较短,其行为与老年多发性硬化症患者相似:为期两年的前瞻性研究包括两组病程相似的年轻(18-35 岁)和老年(50 岁)多发性硬化症患者。研究人员进行了身体和认知评估、3 T 脑磁共振成像(MRI)和光学相干断层扫描视网膜神经纤维层(RNFL)测量。LTL通过定量聚合酶链反应检测法进行测量:结果:共纳入约 105 名患者,其中 57 人为年轻人,48 人为老年人。老年患者(0.61 对 0.57,p = 0.0081)和男性患者(女性,0.60;男性,0.59;p = 0.01335)LTL 较短。年龄每增加 10 岁,LTL 缩短 0.02 U。在老年人中,LTL 与病程(p = 0.05)、吸烟(p = 0.03)、残疾状况扩展量表(EDSS;p = 0.004)、9HPT(p = 0.00007)、高效疗法(p = 0.001)、脑病变体积(BLV)(p = 0.011)和 T2 病变数量(p = 0.01)相关。在年轻患者中,LTL 与临床或放射学变量无关。LTL每缩短0.1 U,灰质体积减少1.75 cm3,白质体积减少1.78 cm3:结论:LTL与老年人的残疾和BLV相关。结论:LTL与老年人的残疾和BLV相关,除了LTL缩短外,其他变量也应被视为可能涉及老年性脑卒中的神经变性机制。
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Telomere length as a biomarker in multiple sclerosis.

Background: Leukocyte telomere length (LTL) shortens with age and may be related to multiple sclerosis (MS).

Objective: We hypothesize that chronologically young people with MS (pwMS) with short LTL behave similarly to older MS subjects.

Methods: Prospective 2-year study including two cohorts of young (18-35 years) and elderly (⩾50 years) pwMS with similar disease duration. Physical and cognitive evaluation, 3 T brain magnetic resonance imaging (MRI) and retinal nerve fiber layer (RNFL) measurement by optical coherence tomography were performed. LTL was measured by quantitative polymerase chain reaction assay.

Results: Around 105 patients were included, 57 young and 48 elderly. LTL was shorter in older patients (0.61 versus 0.57, p = 0.0081) and in males (female, 0.60; male, 0.59; p = 0.01335). For every 10-year increase in age, LTL was 0.02 U shorter. In elderly, LTL correlated with disease duration (p = 0.05), smoking (p = 0.03), Expanded Disability Status Scale (EDSS; p = 0.004), 9HPT (p = 0.00007), high-efficacy therapies (p = 0.001), brain lesion volume (BLV) (p = 0.011), and number of T2 lesions (p = 0.01). In young patients, LTL did not correlate with clinical or radiological variables. For every 0.1 U shorter LTL, gray matter volume decreased 1.75 cm3 and white matter volume 1.78 cm3.

Conclusion: LTL correlated with disability and BLV in elderly. Besides LTL shortening, other variables should be considered as mechanisms of neurodegeneration that might be involved in aging pwMS.

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来源期刊
Multiple Sclerosis Journal
Multiple Sclerosis Journal 医学-临床神经学
CiteScore
10.90
自引率
6.90%
发文量
186
审稿时长
3-8 weeks
期刊介绍: Multiple Sclerosis Journal is a peer-reviewed international journal that focuses on all aspects of multiple sclerosis, neuromyelitis optica and other related autoimmune diseases of the central nervous system. The journal for your research in the following areas: * __Biologic basis:__ pathology, myelin biology, pathophysiology of the blood/brain barrier, axo-glial pathobiology, remyelination, virology and microbiome, immunology, proteomics * __Epidemology and genetics:__ genetics epigenetics, epidemiology * __Clinical and Neuroimaging:__ clinical neurology, biomarkers, neuroimaging and clinical outcome measures * __Therapeutics and rehabilitation:__ therapeutics, rehabilitation, psychology, neuroplasticity, neuroprotection, and systematic management Print ISSN: 1352-4585
期刊最新文献
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