Maria Agustina Piedrabuena, Jorge Correale, Mauricio Franco Farez, Sofia Rodríguez Murúa, Carlos Martínez Canyazo, Marcela Fiol, Mariano Marrodan, Maria Celica Ysrraelit
{"title":"作为多发性硬化症生物标志物的端粒长度。","authors":"Maria Agustina Piedrabuena, Jorge Correale, Mauricio Franco Farez, Sofia Rodríguez Murúa, Carlos Martínez Canyazo, Marcela Fiol, Mariano Marrodan, Maria Celica Ysrraelit","doi":"10.1177/13524585241273054","DOIUrl":null,"url":null,"abstract":"<p><strong>Background: </strong>Leukocyte telomere length (LTL) shortens with age and may be related to multiple sclerosis (MS).</p><p><strong>Objective: </strong>We hypothesize that chronologically young people with MS (pwMS) with short LTL behave similarly to older MS subjects.</p><p><strong>Methods: </strong>Prospective 2-year study including two cohorts of young (18-35 years) and elderly (⩾50 years) pwMS with similar disease duration. Physical and cognitive evaluation, 3 T brain magnetic resonance imaging (MRI) and retinal nerve fiber layer (RNFL) measurement by optical coherence tomography were performed. LTL was measured by quantitative polymerase chain reaction assay.</p><p><strong>Results: </strong>Around 105 patients were included, 57 young and 48 elderly. LTL was shorter in older patients (0.61 versus 0.57, <i>p</i> = 0.0081) and in males (female, 0.60; male, 0.59; <i>p</i> = 0.01335). For every 10-year increase in age, LTL was 0.02 U shorter. In elderly, LTL correlated with disease duration (<i>p</i> = 0.05), smoking (<i>p</i> = 0.03), Expanded Disability Status Scale (EDSS; <i>p</i> = 0.004), 9HPT (<i>p</i> = 0.00007), high-efficacy therapies (<i>p</i> = 0.001), brain lesion volume (BLV) (<i>p</i> = 0.011), and number of T2 lesions (<i>p</i> = 0.01). In young patients, LTL did not correlate with clinical or radiological variables. For every 0.1 U shorter LTL, gray matter volume decreased 1.75 cm<sup>3</sup> and white matter volume 1.78 cm<sup>3</sup>.</p><p><strong>Conclusion: </strong>LTL correlated with disability and BLV in elderly. Besides LTL shortening, other variables should be considered as mechanisms of neurodegeneration that might be involved in aging pwMS.</p>","PeriodicalId":18874,"journal":{"name":"Multiple Sclerosis Journal","volume":null,"pages":null},"PeriodicalIF":4.8000,"publicationDate":"2024-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":"{\"title\":\"Telomere length as a biomarker in multiple sclerosis.\",\"authors\":\"Maria Agustina Piedrabuena, Jorge Correale, Mauricio Franco Farez, Sofia Rodríguez Murúa, Carlos Martínez Canyazo, Marcela Fiol, Mariano Marrodan, Maria Celica Ysrraelit\",\"doi\":\"10.1177/13524585241273054\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<p><strong>Background: </strong>Leukocyte telomere length (LTL) shortens with age and may be related to multiple sclerosis (MS).</p><p><strong>Objective: </strong>We hypothesize that chronologically young people with MS (pwMS) with short LTL behave similarly to older MS subjects.</p><p><strong>Methods: </strong>Prospective 2-year study including two cohorts of young (18-35 years) and elderly (⩾50 years) pwMS with similar disease duration. Physical and cognitive evaluation, 3 T brain magnetic resonance imaging (MRI) and retinal nerve fiber layer (RNFL) measurement by optical coherence tomography were performed. LTL was measured by quantitative polymerase chain reaction assay.</p><p><strong>Results: </strong>Around 105 patients were included, 57 young and 48 elderly. LTL was shorter in older patients (0.61 versus 0.57, <i>p</i> = 0.0081) and in males (female, 0.60; male, 0.59; <i>p</i> = 0.01335). For every 10-year increase in age, LTL was 0.02 U shorter. In elderly, LTL correlated with disease duration (<i>p</i> = 0.05), smoking (<i>p</i> = 0.03), Expanded Disability Status Scale (EDSS; <i>p</i> = 0.004), 9HPT (<i>p</i> = 0.00007), high-efficacy therapies (<i>p</i> = 0.001), brain lesion volume (BLV) (<i>p</i> = 0.011), and number of T2 lesions (<i>p</i> = 0.01). In young patients, LTL did not correlate with clinical or radiological variables. For every 0.1 U shorter LTL, gray matter volume decreased 1.75 cm<sup>3</sup> and white matter volume 1.78 cm<sup>3</sup>.</p><p><strong>Conclusion: </strong>LTL correlated with disability and BLV in elderly. Besides LTL shortening, other variables should be considered as mechanisms of neurodegeneration that might be involved in aging pwMS.</p>\",\"PeriodicalId\":18874,\"journal\":{\"name\":\"Multiple Sclerosis Journal\",\"volume\":null,\"pages\":null},\"PeriodicalIF\":4.8000,\"publicationDate\":\"2024-09-01\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Multiple Sclerosis Journal\",\"FirstCategoryId\":\"3\",\"ListUrlMain\":\"https://doi.org/10.1177/13524585241273054\",\"RegionNum\":2,\"RegionCategory\":\"医学\",\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"2024/9/9 0:00:00\",\"PubModel\":\"Epub\",\"JCR\":\"Q1\",\"JCRName\":\"CLINICAL NEUROLOGY\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Multiple Sclerosis Journal","FirstCategoryId":"3","ListUrlMain":"https://doi.org/10.1177/13524585241273054","RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"2024/9/9 0:00:00","PubModel":"Epub","JCR":"Q1","JCRName":"CLINICAL NEUROLOGY","Score":null,"Total":0}
Telomere length as a biomarker in multiple sclerosis.
Background: Leukocyte telomere length (LTL) shortens with age and may be related to multiple sclerosis (MS).
Objective: We hypothesize that chronologically young people with MS (pwMS) with short LTL behave similarly to older MS subjects.
Methods: Prospective 2-year study including two cohorts of young (18-35 years) and elderly (⩾50 years) pwMS with similar disease duration. Physical and cognitive evaluation, 3 T brain magnetic resonance imaging (MRI) and retinal nerve fiber layer (RNFL) measurement by optical coherence tomography were performed. LTL was measured by quantitative polymerase chain reaction assay.
Results: Around 105 patients were included, 57 young and 48 elderly. LTL was shorter in older patients (0.61 versus 0.57, p = 0.0081) and in males (female, 0.60; male, 0.59; p = 0.01335). For every 10-year increase in age, LTL was 0.02 U shorter. In elderly, LTL correlated with disease duration (p = 0.05), smoking (p = 0.03), Expanded Disability Status Scale (EDSS; p = 0.004), 9HPT (p = 0.00007), high-efficacy therapies (p = 0.001), brain lesion volume (BLV) (p = 0.011), and number of T2 lesions (p = 0.01). In young patients, LTL did not correlate with clinical or radiological variables. For every 0.1 U shorter LTL, gray matter volume decreased 1.75 cm3 and white matter volume 1.78 cm3.
Conclusion: LTL correlated with disability and BLV in elderly. Besides LTL shortening, other variables should be considered as mechanisms of neurodegeneration that might be involved in aging pwMS.
期刊介绍:
Multiple Sclerosis Journal is a peer-reviewed international journal that focuses on all aspects of multiple sclerosis, neuromyelitis optica and other related autoimmune diseases of the central nervous system.
The journal for your research in the following areas:
* __Biologic basis:__ pathology, myelin biology, pathophysiology of the blood/brain barrier, axo-glial pathobiology, remyelination, virology and microbiome, immunology, proteomics
* __Epidemology and genetics:__ genetics epigenetics, epidemiology
* __Clinical and Neuroimaging:__ clinical neurology, biomarkers, neuroimaging and clinical outcome measures
* __Therapeutics and rehabilitation:__ therapeutics, rehabilitation, psychology, neuroplasticity, neuroprotection, and systematic management
Print ISSN: 1352-4585