{"title":"用于同时测量舍曲林和丁螺环酮神经安定药物的 fMW@TiO2@MoS2-Sm2S3/GCE 电化学纳米传感器的制备方法","authors":"","doi":"10.1016/j.surfin.2024.105063","DOIUrl":null,"url":null,"abstract":"<div><p>In this paper for the first time, due to the importance of simultaneous administration of sertraline (SRT) and buspirone (BPH), a sensitive electrochemical nanosensor was fabricated and used for simultaneous measurement of them. Firstly, fMW@TiO<sub>2</sub>@MoS<sub>2</sub>-Sm<sub>2</sub>S<sub>3</sub> was synthesized and characterized by different techniques. The performance of fMW@TiO<sub>2</sub>@MoS<sub>2</sub>-Sm<sub>2</sub>S<sub>3</sub>/GCE nanocomposite was investigated for simultaneous quantifications of SRT and BPH using different electrochemical methods. Response surface methodology (RSM) indicated that pH 7.0 for phosphate buffer solutions (PBS), scan rate of 0.08 V s<sup>-1</sup>, accumulation potential of 0.4 V and accumulation time of 125 s in CHA get maximum anodic currents. The anodic peak current densities of SRT and BPH drugs were improved excellently on the surface of fMW@TiO<sub>2</sub>@MoS<sub>2</sub>-Sm<sub>2</sub>S<sub>3</sub>/GCE compared to bare GCE. With the DPV method, the linear response 1.53–38.46, 38.46–74.07 µM and 1.11–29.12, 29.12–90.90 µM were obtained for SRT and BPH, respectively. Also, the detection limit of 0.50 µM and 0.36 µM were acquired for SRT and BPH, respectively. The catalytic rate constants were calculated to be 3.63 × 10<sup>7</sup> and 2.80 × 10<sup>7</sup> cm<sup>3</sup> mol<sup>-1</sup> s<sup>-1</sup> for SRT and BPH, respectively. The practical application of the fMW@TiO<sub>2</sub>@MoS<sub>2</sub>-Sm<sub>2</sub>S<sub>3</sub> for measurements of the SRT and BPH in human plasma and tablets showed good recovery percentage.</p></div>","PeriodicalId":22081,"journal":{"name":"Surfaces and Interfaces","volume":null,"pages":null},"PeriodicalIF":5.7000,"publicationDate":"2024-09-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":"{\"title\":\"Fabrication of fMW@TiO2@MoS2-Sm2S3/GCE electrochemical nanosensor for simultaneous measurement of sertraline and buspirone neuroleptic drugs\",\"authors\":\"\",\"doi\":\"10.1016/j.surfin.2024.105063\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<div><p>In this paper for the first time, due to the importance of simultaneous administration of sertraline (SRT) and buspirone (BPH), a sensitive electrochemical nanosensor was fabricated and used for simultaneous measurement of them. Firstly, fMW@TiO<sub>2</sub>@MoS<sub>2</sub>-Sm<sub>2</sub>S<sub>3</sub> was synthesized and characterized by different techniques. The performance of fMW@TiO<sub>2</sub>@MoS<sub>2</sub>-Sm<sub>2</sub>S<sub>3</sub>/GCE nanocomposite was investigated for simultaneous quantifications of SRT and BPH using different electrochemical methods. Response surface methodology (RSM) indicated that pH 7.0 for phosphate buffer solutions (PBS), scan rate of 0.08 V s<sup>-1</sup>, accumulation potential of 0.4 V and accumulation time of 125 s in CHA get maximum anodic currents. The anodic peak current densities of SRT and BPH drugs were improved excellently on the surface of fMW@TiO<sub>2</sub>@MoS<sub>2</sub>-Sm<sub>2</sub>S<sub>3</sub>/GCE compared to bare GCE. With the DPV method, the linear response 1.53–38.46, 38.46–74.07 µM and 1.11–29.12, 29.12–90.90 µM were obtained for SRT and BPH, respectively. Also, the detection limit of 0.50 µM and 0.36 µM were acquired for SRT and BPH, respectively. The catalytic rate constants were calculated to be 3.63 × 10<sup>7</sup> and 2.80 × 10<sup>7</sup> cm<sup>3</sup> mol<sup>-1</sup> s<sup>-1</sup> for SRT and BPH, respectively. The practical application of the fMW@TiO<sub>2</sub>@MoS<sub>2</sub>-Sm<sub>2</sub>S<sub>3</sub> for measurements of the SRT and BPH in human plasma and tablets showed good recovery percentage.</p></div>\",\"PeriodicalId\":22081,\"journal\":{\"name\":\"Surfaces and Interfaces\",\"volume\":null,\"pages\":null},\"PeriodicalIF\":5.7000,\"publicationDate\":\"2024-09-05\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Surfaces and Interfaces\",\"FirstCategoryId\":\"88\",\"ListUrlMain\":\"https://www.sciencedirect.com/science/article/pii/S2468023024012197\",\"RegionNum\":2,\"RegionCategory\":\"材料科学\",\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"Q2\",\"JCRName\":\"CHEMISTRY, PHYSICAL\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Surfaces and Interfaces","FirstCategoryId":"88","ListUrlMain":"https://www.sciencedirect.com/science/article/pii/S2468023024012197","RegionNum":2,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q2","JCRName":"CHEMISTRY, PHYSICAL","Score":null,"Total":0}
Fabrication of fMW@TiO2@MoS2-Sm2S3/GCE electrochemical nanosensor for simultaneous measurement of sertraline and buspirone neuroleptic drugs
In this paper for the first time, due to the importance of simultaneous administration of sertraline (SRT) and buspirone (BPH), a sensitive electrochemical nanosensor was fabricated and used for simultaneous measurement of them. Firstly, fMW@TiO2@MoS2-Sm2S3 was synthesized and characterized by different techniques. The performance of fMW@TiO2@MoS2-Sm2S3/GCE nanocomposite was investigated for simultaneous quantifications of SRT and BPH using different electrochemical methods. Response surface methodology (RSM) indicated that pH 7.0 for phosphate buffer solutions (PBS), scan rate of 0.08 V s-1, accumulation potential of 0.4 V and accumulation time of 125 s in CHA get maximum anodic currents. The anodic peak current densities of SRT and BPH drugs were improved excellently on the surface of fMW@TiO2@MoS2-Sm2S3/GCE compared to bare GCE. With the DPV method, the linear response 1.53–38.46, 38.46–74.07 µM and 1.11–29.12, 29.12–90.90 µM were obtained for SRT and BPH, respectively. Also, the detection limit of 0.50 µM and 0.36 µM were acquired for SRT and BPH, respectively. The catalytic rate constants were calculated to be 3.63 × 107 and 2.80 × 107 cm3 mol-1 s-1 for SRT and BPH, respectively. The practical application of the fMW@TiO2@MoS2-Sm2S3 for measurements of the SRT and BPH in human plasma and tablets showed good recovery percentage.
期刊介绍:
The aim of the journal is to provide a respectful outlet for ''sound science'' papers in all research areas on surfaces and interfaces. We define sound science papers as papers that describe new and well-executed research, but that do not necessarily provide brand new insights or are merely a description of research results.
Surfaces and Interfaces publishes research papers in all fields of surface science which may not always find the right home on first submission to our Elsevier sister journals (Applied Surface, Surface and Coatings Technology, Thin Solid Films)