Fabrication of fMW@TiO2@MoS2-Sm2S3/GCE electrochemical nanosensor for simultaneous measurement of sertraline and buspirone neuroleptic drugs

In this paper for the first time, due to the importance of simultaneous administration of sertraline (SRT) and buspirone (BPH), a sensitive electrochemical nanosensor was fabricated and used for simultaneous measurement of them. Firstly, fMW@TiO₂@MoS₂-Sm₂S₃ was synthesized and characterized by different techniques. The performance of fMW@TiO₂@MoS₂-Sm₂S₃/GCE nanocomposite was investigated for simultaneous quantifications of SRT and BPH using different electrochemical methods. Response surface methodology (RSM) indicated that pH 7.0 for phosphate buffer solutions (PBS), scan rate of 0.08 V s^-1, accumulation potential of 0.4 V and accumulation time of 125 s in CHA get maximum anodic currents. The anodic peak current densities of SRT and BPH drugs were improved excellently on the surface of fMW@TiO₂@MoS₂-Sm₂S₃/GCE compared to bare GCE. With the DPV method, the linear response 1.53–38.46, 38.46–74.07 µM and 1.11–29.12, 29.12–90.90 µM were obtained for SRT and BPH, respectively. Also, the detection limit of 0.50 µM and 0.36 µM were acquired for SRT and BPH, respectively. The catalytic rate constants were calculated to be 3.63 × 10⁷ and 2.80 × 10⁷ cm³ mol^-1 s^-1 for SRT and BPH, respectively. The practical application of the fMW@TiO₂@MoS₂-Sm₂S₃ for measurements of the SRT and BPH in human plasma and tablets showed good recovery percentage.