{"title":"降视素受体拮抗剂可预防阿片类药物成瘾","authors":"Jimmy J. Fraigne, John H. Peever","doi":"10.1038/s44220-024-00300-7","DOIUrl":null,"url":null,"abstract":"The opioid abuse epidemic is a major health concern that requires new pain management strategies. Findings now show that suvorexant, a dual hypocretin receptor antagonist, reverses the anatomical and circuit alterations induced by opioids and decreases addictive behavior while maintaining the analgesic properties of the drugs.","PeriodicalId":74247,"journal":{"name":"Nature mental health","volume":null,"pages":null},"PeriodicalIF":0.0000,"publicationDate":"2024-08-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":"{\"title\":\"Hypocretin receptor antagonists prevent opioid addiction\",\"authors\":\"Jimmy J. Fraigne, John H. Peever\",\"doi\":\"10.1038/s44220-024-00300-7\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"The opioid abuse epidemic is a major health concern that requires new pain management strategies. Findings now show that suvorexant, a dual hypocretin receptor antagonist, reverses the anatomical and circuit alterations induced by opioids and decreases addictive behavior while maintaining the analgesic properties of the drugs.\",\"PeriodicalId\":74247,\"journal\":{\"name\":\"Nature mental health\",\"volume\":null,\"pages\":null},\"PeriodicalIF\":0.0000,\"publicationDate\":\"2024-08-23\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Nature mental health\",\"FirstCategoryId\":\"1085\",\"ListUrlMain\":\"https://www.nature.com/articles/s44220-024-00300-7\",\"RegionNum\":0,\"RegionCategory\":null,\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"\",\"JCRName\":\"\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Nature mental health","FirstCategoryId":"1085","ListUrlMain":"https://www.nature.com/articles/s44220-024-00300-7","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"","JCRName":"","Score":null,"Total":0}
The opioid abuse epidemic is a major health concern that requires new pain management strategies. Findings now show that suvorexant, a dual hypocretin receptor antagonist, reverses the anatomical and circuit alterations induced by opioids and decreases addictive behavior while maintaining the analgesic properties of the drugs.
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