心血管-肾脏-代谢综合征不同阶段与全因死亡风险之间的关系

IF 4.9 2区 医学 Q1 CARDIAC & CARDIOVASCULAR SYSTEMS Atherosclerosis Pub Date : 2024-08-30 DOI:10.1016/j.atherosclerosis.2024.118585
Na Li , Yaqi Li , Liufu Cui , Rong Shu , Haicheng Song , Jierui Wang , Shuohua Chen , Bailu Liu , Huijing Shi , Huanqing Gao , Tao Huang , Xiang Gao , Tingting Geng , Shouling Wu
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引用次数: 0

摘要

背景和目的不良的心血管-肾脏-代谢(CKM)健康状况是全因死亡率的主要决定因素,给全球公共卫生系统和社会经济造成了沉重负担。然而,不同阶段的 CKM 综合征与全因死亡风险之间的关系仍不清楚。本研究旨在评估不同阶段的 CKM 综合征与全因死亡风险之间的关系。结果在中位随访 15.0 (14.7-15.2) 年期间,我们共发现了 14 805 例全因死亡病例。CKM综合征的分期与全因死亡风险呈正相关(p-trend <0.001)。与 0 期相比,经多变量调整的全因死亡率 HRs(95 % CIs)分别为:1 期 1.24(1.06-1.45),2 期 1.72(1.48-2.00),3 期 2.58(2.22-3.01),4 期 3.73(3.19-4.37)。结论我们的数据显示,CKM 综合征的分期越高,全因死亡的风险越高,年轻成人的相关性尤其明显。该研究强调,有必要根据 CKM 综合征的不同阶段制定有针对性的公共卫生策略和临床管理,以减轻其对个人和医疗系统造成的负担。
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Association between different stages of cardiovascular-kidney-metabolic syndrome and the risk of all-cause mortality

Background and aims

Poor cardiovascular-kidney-metabolic (CKM) health is a major determinant of all-cause mortality, which poses a significant burden on global public health systems and socio-economics. However, the association between different stages of CKM syndrome and the risk of all-cause mortality remains unclear. This study aimed to evaluate the association between different stages of CKM syndrome and risk of all-cause mortality.

Methods

A total of 97,777 adults from the Kailuan Study were included. Cox proportional hazards regression models were applied to estimate hazard ratios (HRs) and 95 % confidence intervals (CIs) of all-cause mortality according to different stages of CKM syndrome.

Results

Over a median follow-up of 15.0 (14.7–15.2) years, we identified 14,805 all-cause mortality cases. The stage of CKM syndrome was positively associated with the risk of all-cause mortality (p-trend <0.001). Compared with Stage 0, the multivariable-adjusted HRs (95 % CIs) of all-cause mortality were 1.24 (1.06–1.45) for Stage 1, 1.72 (1.48–2.00) for Stage 2, 2.58 (2.22–3.01) for Stage 3 and 3.73 (3.19–4.37) for Stage 4. Moreover, the observed associations were more pronounced in younger adults (aged <60 years) compared with older adults (p for interaction <0.001).

Conclusions

Our data showed that a higher stage of CKM syndrome was associated with a higher risk of all-cause mortality, with a particularly pronounced association observed in younger adults. The study emphasized the need for targeted public health strategies and clinical management tailored to the stages of CKM syndrome, aiming to alleviate its burden on individuals and healthcare systems.

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来源期刊
Atherosclerosis
Atherosclerosis 医学-外周血管病
CiteScore
9.80
自引率
3.80%
发文量
1269
审稿时长
36 days
期刊介绍: Atherosclerosis has an open access mirror journal Atherosclerosis: X, sharing the same aims and scope, editorial team, submission system and rigorous peer review. Atherosclerosis brings together, from all sources, papers concerned with investigation on atherosclerosis, its risk factors and clinical manifestations. Atherosclerosis covers basic and translational, clinical and population research approaches to arterial and vascular biology and disease, as well as their risk factors including: disturbances of lipid and lipoprotein metabolism, diabetes and hypertension, thrombosis, and inflammation. The Editors are interested in original or review papers dealing with the pathogenesis, environmental, genetic and epigenetic basis, diagnosis or treatment of atherosclerosis and related diseases as well as their risk factors.
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