Na Li , Yaqi Li , Liufu Cui , Rong Shu , Haicheng Song , Jierui Wang , Shuohua Chen , Bailu Liu , Huijing Shi , Huanqing Gao , Tao Huang , Xiang Gao , Tingting Geng , Shouling Wu
{"title":"心血管-肾脏-代谢综合征不同阶段与全因死亡风险之间的关系","authors":"Na Li , Yaqi Li , Liufu Cui , Rong Shu , Haicheng Song , Jierui Wang , Shuohua Chen , Bailu Liu , Huijing Shi , Huanqing Gao , Tao Huang , Xiang Gao , Tingting Geng , Shouling Wu","doi":"10.1016/j.atherosclerosis.2024.118585","DOIUrl":null,"url":null,"abstract":"<div><h3>Background and aims</h3><p>Poor cardiovascular-kidney-metabolic (CKM) health is a major determinant of all-cause mortality, which poses a significant burden on global public health systems and socio-economics. However, the association between different stages of CKM syndrome and the risk of all-cause mortality remains unclear. This study aimed to evaluate the association between different stages of CKM syndrome and risk of all-cause mortality.</p></div><div><h3>Methods</h3><p>A total of 97,777 adults from the Kailuan Study were included. Cox proportional hazards regression models were applied to estimate hazard ratios (HRs) and 95 % confidence intervals (CIs) of all-cause mortality according to different stages of CKM syndrome.</p></div><div><h3>Results</h3><p>Over a median follow-up of 15.0 (14.7–15.2) years, we identified 14,805 all-cause mortality cases. The stage of CKM syndrome was positively associated with the risk of all-cause mortality (<em>p</em>-trend <0.001). Compared with Stage 0, the multivariable-adjusted HRs (95 % CIs) of all-cause mortality were 1.24 (1.06–1.45) for Stage 1, 1.72 (1.48–2.00) for Stage 2, 2.58 (2.22–3.01) for Stage 3 and 3.73 (3.19–4.37) for Stage 4. Moreover, the observed associations were more pronounced in younger adults (aged <60 years) compared with older adults (<em>p</em> for interaction <0.001).</p></div><div><h3>Conclusions</h3><p>Our data showed that a higher stage of CKM syndrome was associated with a higher risk of all-cause mortality, with a particularly pronounced association observed in younger adults. The study emphasized the need for targeted public health strategies and clinical management tailored to the stages of CKM syndrome, aiming to alleviate its burden on individuals and healthcare systems.</p></div>","PeriodicalId":8623,"journal":{"name":"Atherosclerosis","volume":null,"pages":null},"PeriodicalIF":4.9000,"publicationDate":"2024-08-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":"{\"title\":\"Association between different stages of cardiovascular-kidney-metabolic syndrome and the risk of all-cause mortality\",\"authors\":\"Na Li , Yaqi Li , Liufu Cui , Rong Shu , Haicheng Song , Jierui Wang , Shuohua Chen , Bailu Liu , Huijing Shi , Huanqing Gao , Tao Huang , Xiang Gao , Tingting Geng , Shouling Wu\",\"doi\":\"10.1016/j.atherosclerosis.2024.118585\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<div><h3>Background and aims</h3><p>Poor cardiovascular-kidney-metabolic (CKM) health is a major determinant of all-cause mortality, which poses a significant burden on global public health systems and socio-economics. However, the association between different stages of CKM syndrome and the risk of all-cause mortality remains unclear. This study aimed to evaluate the association between different stages of CKM syndrome and risk of all-cause mortality.</p></div><div><h3>Methods</h3><p>A total of 97,777 adults from the Kailuan Study were included. Cox proportional hazards regression models were applied to estimate hazard ratios (HRs) and 95 % confidence intervals (CIs) of all-cause mortality according to different stages of CKM syndrome.</p></div><div><h3>Results</h3><p>Over a median follow-up of 15.0 (14.7–15.2) years, we identified 14,805 all-cause mortality cases. The stage of CKM syndrome was positively associated with the risk of all-cause mortality (<em>p</em>-trend <0.001). Compared with Stage 0, the multivariable-adjusted HRs (95 % CIs) of all-cause mortality were 1.24 (1.06–1.45) for Stage 1, 1.72 (1.48–2.00) for Stage 2, 2.58 (2.22–3.01) for Stage 3 and 3.73 (3.19–4.37) for Stage 4. Moreover, the observed associations were more pronounced in younger adults (aged <60 years) compared with older adults (<em>p</em> for interaction <0.001).</p></div><div><h3>Conclusions</h3><p>Our data showed that a higher stage of CKM syndrome was associated with a higher risk of all-cause mortality, with a particularly pronounced association observed in younger adults. 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Association between different stages of cardiovascular-kidney-metabolic syndrome and the risk of all-cause mortality
Background and aims
Poor cardiovascular-kidney-metabolic (CKM) health is a major determinant of all-cause mortality, which poses a significant burden on global public health systems and socio-economics. However, the association between different stages of CKM syndrome and the risk of all-cause mortality remains unclear. This study aimed to evaluate the association between different stages of CKM syndrome and risk of all-cause mortality.
Methods
A total of 97,777 adults from the Kailuan Study were included. Cox proportional hazards regression models were applied to estimate hazard ratios (HRs) and 95 % confidence intervals (CIs) of all-cause mortality according to different stages of CKM syndrome.
Results
Over a median follow-up of 15.0 (14.7–15.2) years, we identified 14,805 all-cause mortality cases. The stage of CKM syndrome was positively associated with the risk of all-cause mortality (p-trend <0.001). Compared with Stage 0, the multivariable-adjusted HRs (95 % CIs) of all-cause mortality were 1.24 (1.06–1.45) for Stage 1, 1.72 (1.48–2.00) for Stage 2, 2.58 (2.22–3.01) for Stage 3 and 3.73 (3.19–4.37) for Stage 4. Moreover, the observed associations were more pronounced in younger adults (aged <60 years) compared with older adults (p for interaction <0.001).
Conclusions
Our data showed that a higher stage of CKM syndrome was associated with a higher risk of all-cause mortality, with a particularly pronounced association observed in younger adults. The study emphasized the need for targeted public health strategies and clinical management tailored to the stages of CKM syndrome, aiming to alleviate its burden on individuals and healthcare systems.
期刊介绍:
Atherosclerosis has an open access mirror journal Atherosclerosis: X, sharing the same aims and scope, editorial team, submission system and rigorous peer review.
Atherosclerosis brings together, from all sources, papers concerned with investigation on atherosclerosis, its risk factors and clinical manifestations. Atherosclerosis covers basic and translational, clinical and population research approaches to arterial and vascular biology and disease, as well as their risk factors including: disturbances of lipid and lipoprotein metabolism, diabetes and hypertension, thrombosis, and inflammation. The Editors are interested in original or review papers dealing with the pathogenesis, environmental, genetic and epigenetic basis, diagnosis or treatment of atherosclerosis and related diseases as well as their risk factors.