职业和业余时间体育活动与全因死亡率的关系:个体参与者数据荟萃分析

IF 11.6 1区 医学 Q1 SPORT SCIENCES British Journal of Sports Medicine Pub Date : 2024-09-10 DOI:10.1136/bjsports-2024-108117
Pieter Coenen, Maaike A Huysmans, Andreas Holtermann, Richard P Troiano, Paul Jarle Mork, Steinar Krokstad, Els Clays, Bart Cillekens, Dirk De Bacquer, Mette Aadahl, Line Lund Kårhus, Anette Sjøl, Lars Bo Andersen, Jussi Kauhanen, Ari Voutilainen, Richard M Pulsford, Emmanuel Stamatakis, Uri Goldbourt, Annette Peters, Barbara Thorand, Annika Rosengren, Lena Björck, Kyle Sprow, Kristin Franzon, Miguel Rodriguez-Barranco, Leila Luján-Barroso, Anders Knutsson, Lars Alfredsson, Martin Bahls, Till Ittermann, Alexander Kluttig, Lamiaa Hassan, Miriam Wanner, Matthias Bopp, Jacob Louis Marott, Peter Schnohr, Børge Grønne Nordestgaard, Knut Eirik Dalene, Ulf Ekelund, Johan Clausen, Magnus Thorsten Jensen, Christina Bjørk Petersen, Niklas Krause, Jos Twisk, Willem van Mechelen, Allard J van der Beek
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Adjusted for LTPA, body mass index, age, smoking and education level, summary (ie, stage 2) hazard ration (HRs) and 95% confidence interval (95% CI) for low, moderate and high OPA among men (n=2 96 134) were 1.01 (0.99 to 1.03), 1.05 (1.01 to 1.10) and 1.12 (1.03 to 1.23), respectively. For women (n=2 94 364), HRs (95% CI) were 0.98 (0.92 to 1.04), 0.96 (0.92 to 1.00) and 0.97 (0.86 to 1.10), respectively. In contrast, higher levels of LTPA were inversely associated with mortality for both genders. For example, for women HR for low, moderate and high compared with sedentary LTPA were 0.85 (0.81 to 0.89), 0.78 (0.74 to 0.81) and 0.75 (0.65 to 0.88), respectively. Effects were attenuated when adjusting for income (although data on income were available from only 9 and 6 studies, for men and women, respectively). Conclusion Our findings indicate that OPA may not result in the same beneficial health effects as LTPA. Data may be obtained from a third party and are not publicly available. 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引用次数: 0

摘要

目标 不同体力活动领域(即闲暇、工作和交通)对健康的影响通常被认为是积极的。我们利用 "积极工人 "联盟的数据,评估了职业和闲暇时间体育锻炼(OPA 和 LTPA)与全因死亡率之间的独立关联。设计 两阶段个体参与者数据荟萃分析。数据来源 已发表和未发表的队列研究数据。资格标准 年龄在 18-65 岁之间的工作参与者。方法 在统一数据后,我们评估了 OPA 和 LTPA 与全因死亡率的关系。在第 1 阶段,我们使用 Cox 生存回归法对每项研究的数据进行了单独分析;在第 2 阶段,我们使用随机效应模型对各项研究的结果进行了汇总。结果 在来自 11 个国家、多达 590 497 名参与者的 22 项研究中,在平均 23.1 年(标度:6.8)的随访期间,99 743 名参与者(16%)死亡。经LTPA、体重指数、年龄、吸烟和教育水平调整后,男性(n=2 96 134)低、中和高OPA的总危险比(即第2阶段)和95%置信区间(95% CI)分别为1.01(0.99至1.03)、1.05(1.01至1.10)和1.12(1.03至1.23)。女性(n=2 94 364)的HRs(95% CI)分别为0.98(0.92至1.04)、0.96(0.92至1.00)和0.97(0.86至1.10)。相比之下,LTPA水平越高,男女死亡率越低。例如,与久坐不动的LTPA相比,女性低、中、高LTPA的死亡率分别为0.85(0.81至0.89)、0.78(0.74至0.81)和0.75(0.65至0.88)。在对收入进行调整后,效果有所减弱(尽管只有 9 项研究提供了收入数据,6 项研究提供了男性和女性收入数据)。结论 我们的研究结果表明,OPA 对健康的益处可能不如 LTPA。数据可能来自第三方,不对外公开。本手稿提供了所有汇总数据,包括补充文件。部分个人参与数据可应要求提供,其他部分可从第三方获取,但不对外公开。
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Associations of occupational and leisure-time physical activity with all-cause mortality: an individual participant data meta-analysis
Objective Health effects of different physical activity domains (ie, during leisure time, work and transport) are generally considered positive. Using Active Worker consortium data, we assessed independent associations of occupational and leisure-time physical activity (OPA and LTPA) with all-cause mortality. Design Two-stage individual participant data meta-analysis. Data source Published and unpublished cohort study data. Eligibility criteria Working participants aged 18–65 years. Methods After data harmonisation, we assessed associations of OPA and LTPA with all-cause mortality. In stage 1, we analysed data from each study separately using Cox survival regression, and in stage 2, we pooled individual study findings with random-effects modelling. Results In 22 studies with up to 590 497 participants from 11 countries, during a mean follow-up of 23.1 (SD: 6.8) years, 99 743 (16%) participants died. Adjusted for LTPA, body mass index, age, smoking and education level, summary (ie, stage 2) hazard ration (HRs) and 95% confidence interval (95% CI) for low, moderate and high OPA among men (n=2 96 134) were 1.01 (0.99 to 1.03), 1.05 (1.01 to 1.10) and 1.12 (1.03 to 1.23), respectively. For women (n=2 94 364), HRs (95% CI) were 0.98 (0.92 to 1.04), 0.96 (0.92 to 1.00) and 0.97 (0.86 to 1.10), respectively. In contrast, higher levels of LTPA were inversely associated with mortality for both genders. For example, for women HR for low, moderate and high compared with sedentary LTPA were 0.85 (0.81 to 0.89), 0.78 (0.74 to 0.81) and 0.75 (0.65 to 0.88), respectively. Effects were attenuated when adjusting for income (although data on income were available from only 9 and 6 studies, for men and women, respectively). Conclusion Our findings indicate that OPA may not result in the same beneficial health effects as LTPA. Data may be obtained from a third party and are not publicly available. All aggregated data are provided in this manuscript, including the supplementary files. Part of the individual participant are available on request, while other parts may be obtained from a third party and are not publicly available.
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来源期刊
CiteScore
27.10
自引率
4.90%
发文量
217
审稿时长
3-8 weeks
期刊介绍: The British Journal of Sports Medicine (BJSM) is a dynamic platform that presents groundbreaking research, thought-provoking reviews, and meaningful discussions on sport and exercise medicine. Our focus encompasses various clinically-relevant aspects such as physiotherapy, physical therapy, and rehabilitation. With an aim to foster innovation, education, and knowledge translation, we strive to bridge the gap between research and practical implementation in the field. Our multi-media approach, including web, print, video, and audio resources, along with our active presence on social media, connects a global community of healthcare professionals dedicated to treating active individuals.
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