{"title":"含铜锌共取代羟基磷灰石的丝纤维/甲基纤维素复合材料的合成及其在骨组织工程应用中的生物医学潜力","authors":"","doi":"10.1016/j.molstruc.2024.139922","DOIUrl":null,"url":null,"abstract":"<div><p>The primary feature of biomaterials is to aid in the regeneration of damaged tissues and organs. To attain a biomaterial, we fabricated a double mineral (copper and zinc) substituted hydroxyapatite/silk fiber/methylcellulose (CZ-HAP/SF/MC) nanocomposite by the E-Spin method. The as-developed CZ-HAP/SF/MC nanocomposite was characterized by Fourier transform infrared spectroscopy (FT-IR), X-ray diffraction (XRD) and moreover, the fabricated nanocomposites were used to investigate morphological changes, porosity, swelling test, mechanical strength, antibacterial activity and apatite growth. In addition, antimicrobial studies demonstrated that CZ-HAP/SF/MC nanocomposite exhibited excellent antimicrobial activity against <em>S. aureus, E. coli</em> and <em>C. albicans</em> and, the resultant nanocomposite revealed that the CZ-HAP/SF/MC nanocomposite will be an effective implant material for better cell growth in BTE applications.</p></div>","PeriodicalId":16414,"journal":{"name":"Journal of Molecular Structure","volume":null,"pages":null},"PeriodicalIF":4.0000,"publicationDate":"2024-09-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":"{\"title\":\"Synthesis and biomedical potential of silk fiber/methylcellulose composite containing copper and zinc co-substituted hydroxyapatite for bone tissue engineering applications\",\"authors\":\"\",\"doi\":\"10.1016/j.molstruc.2024.139922\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<div><p>The primary feature of biomaterials is to aid in the regeneration of damaged tissues and organs. To attain a biomaterial, we fabricated a double mineral (copper and zinc) substituted hydroxyapatite/silk fiber/methylcellulose (CZ-HAP/SF/MC) nanocomposite by the E-Spin method. The as-developed CZ-HAP/SF/MC nanocomposite was characterized by Fourier transform infrared spectroscopy (FT-IR), X-ray diffraction (XRD) and moreover, the fabricated nanocomposites were used to investigate morphological changes, porosity, swelling test, mechanical strength, antibacterial activity and apatite growth. In addition, antimicrobial studies demonstrated that CZ-HAP/SF/MC nanocomposite exhibited excellent antimicrobial activity against <em>S. aureus, E. coli</em> and <em>C. albicans</em> and, the resultant nanocomposite revealed that the CZ-HAP/SF/MC nanocomposite will be an effective implant material for better cell growth in BTE applications.</p></div>\",\"PeriodicalId\":16414,\"journal\":{\"name\":\"Journal of Molecular Structure\",\"volume\":null,\"pages\":null},\"PeriodicalIF\":4.0000,\"publicationDate\":\"2024-09-03\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Journal of Molecular Structure\",\"FirstCategoryId\":\"92\",\"ListUrlMain\":\"https://www.sciencedirect.com/science/article/pii/S0022286024024311\",\"RegionNum\":2,\"RegionCategory\":\"化学\",\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"Q2\",\"JCRName\":\"CHEMISTRY, PHYSICAL\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Journal of Molecular Structure","FirstCategoryId":"92","ListUrlMain":"https://www.sciencedirect.com/science/article/pii/S0022286024024311","RegionNum":2,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q2","JCRName":"CHEMISTRY, PHYSICAL","Score":null,"Total":0}
引用次数: 0
摘要
生物材料的主要功能是帮助受损组织和器官再生。为了实现这种生物材料,我们采用 E-Spin 法制备了双矿物(铜和锌)取代羟基磷灰石/蚕丝纤维/甲基纤维素(CZ-HAP/SF/MC)纳米复合材料。傅立叶变换红外光谱(FT-IR)和 X 射线衍射(XRD)对所制备的 CZ-HAP/SF/MC 纳米复合材料进行了表征,此外,还对所制备的纳米复合材料的形态变化、孔隙率、膨胀试验、机械强度、抗菌活性和磷灰石生长进行了研究。此外,抗菌研究表明,CZ-HAP/SF/MC 纳米复合材料对金黄色葡萄球菌、大肠杆菌和白僵菌具有极佳的抗菌活性。
Synthesis and biomedical potential of silk fiber/methylcellulose composite containing copper and zinc co-substituted hydroxyapatite for bone tissue engineering applications
The primary feature of biomaterials is to aid in the regeneration of damaged tissues and organs. To attain a biomaterial, we fabricated a double mineral (copper and zinc) substituted hydroxyapatite/silk fiber/methylcellulose (CZ-HAP/SF/MC) nanocomposite by the E-Spin method. The as-developed CZ-HAP/SF/MC nanocomposite was characterized by Fourier transform infrared spectroscopy (FT-IR), X-ray diffraction (XRD) and moreover, the fabricated nanocomposites were used to investigate morphological changes, porosity, swelling test, mechanical strength, antibacterial activity and apatite growth. In addition, antimicrobial studies demonstrated that CZ-HAP/SF/MC nanocomposite exhibited excellent antimicrobial activity against S. aureus, E. coli and C. albicans and, the resultant nanocomposite revealed that the CZ-HAP/SF/MC nanocomposite will be an effective implant material for better cell growth in BTE applications.
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