{"title":"认知功能正常的老年人的葡萄糖代谢和海马体积变小。","authors":"Ayano Shima,Moeko Noguchi-Shinohara,Shutaro Shibata,Yuta Usui,Yasuko Tatewaki,Benjamin Thyreau,Jun Hata,Tomoyuki Ohara,Takanori Honda,Yasuyuki Taki,Shigeyuki Nakaji,Tetsuya Maeda,Masaru Mimura,Kenji Nakashima,Jun-Ichi Iga,Minoru Takebayashi,Hisao Nishijo,Toshiharu Ninomiya,Kenjiro Ono,","doi":"10.1038/s41514-024-00164-2","DOIUrl":null,"url":null,"abstract":"We investigated associations of glycemic measures, and insulin resistance and secretion measures with hippocampal and subfield volumes. In this cross-sectional study, 7400 community-dwelling participants underwent brain MRI and health checkups between 2016 and 2018. Hemoglobin A1c (HbA1c), glycated albumin (GA), homeostasis model assessment for insulin resistance (HOMA-IR), and HOMA of percent β-cell function (HOMA-β) were evaluated. The associations of each measure with a smaller volume of the hippocampus and twelve hippocampal subfields were investigated. As a result, higher HbA1c or GA and lower HOMA-β levels were significantly associated with smaller volumes in multiple hippocampal subfields. Furthermore, even when we analyzed non-diabetic individuals, substantial associations remained between higher GA or lower HOMA-β levels and smaller volumes of the whole hippocampus or the fimbria. Our findings indicate that postprandial glucose fluctuations, postprandial hyperglycemia, and low insulin secretion have a specific effect on the development of smaller hippocampal volume, suggesting that primary prevention of diabetes and/or sufficient glucose control are important for the prevention of dementia.","PeriodicalId":520101,"journal":{"name":"npj Aging","volume":null,"pages":null},"PeriodicalIF":0.0000,"publicationDate":"2024-09-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":"{\"title\":\"Glucose metabolism and smaller hippocampal volume in elderly people with normal cognitive function.\",\"authors\":\"Ayano Shima,Moeko Noguchi-Shinohara,Shutaro Shibata,Yuta Usui,Yasuko Tatewaki,Benjamin Thyreau,Jun Hata,Tomoyuki Ohara,Takanori Honda,Yasuyuki Taki,Shigeyuki Nakaji,Tetsuya Maeda,Masaru Mimura,Kenji Nakashima,Jun-Ichi Iga,Minoru Takebayashi,Hisao Nishijo,Toshiharu Ninomiya,Kenjiro Ono,\",\"doi\":\"10.1038/s41514-024-00164-2\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"We investigated associations of glycemic measures, and insulin resistance and secretion measures with hippocampal and subfield volumes. In this cross-sectional study, 7400 community-dwelling participants underwent brain MRI and health checkups between 2016 and 2018. Hemoglobin A1c (HbA1c), glycated albumin (GA), homeostasis model assessment for insulin resistance (HOMA-IR), and HOMA of percent β-cell function (HOMA-β) were evaluated. The associations of each measure with a smaller volume of the hippocampus and twelve hippocampal subfields were investigated. As a result, higher HbA1c or GA and lower HOMA-β levels were significantly associated with smaller volumes in multiple hippocampal subfields. Furthermore, even when we analyzed non-diabetic individuals, substantial associations remained between higher GA or lower HOMA-β levels and smaller volumes of the whole hippocampus or the fimbria. Our findings indicate that postprandial glucose fluctuations, postprandial hyperglycemia, and low insulin secretion have a specific effect on the development of smaller hippocampal volume, suggesting that primary prevention of diabetes and/or sufficient glucose control are important for the prevention of dementia.\",\"PeriodicalId\":520101,\"journal\":{\"name\":\"npj Aging\",\"volume\":null,\"pages\":null},\"PeriodicalIF\":0.0000,\"publicationDate\":\"2024-09-09\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"npj Aging\",\"FirstCategoryId\":\"1085\",\"ListUrlMain\":\"https://doi.org/10.1038/s41514-024-00164-2\",\"RegionNum\":0,\"RegionCategory\":null,\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"\",\"JCRName\":\"\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"npj Aging","FirstCategoryId":"1085","ListUrlMain":"https://doi.org/10.1038/s41514-024-00164-2","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"","JCRName":"","Score":null,"Total":0}
引用次数: 0
摘要
我们研究了血糖测量、胰岛素抵抗和分泌测量与海马和亚场体积的关联。在这项横断面研究中,7400 名社区居民在 2016 年至 2018 年间接受了脑核磁共振成像和健康体检。对血红蛋白A1c(HbA1c)、糖化白蛋白(GA)、胰岛素抵抗的稳态模型评估(HOMA-IR)和β细胞功能百分比的HOMA(HOMA-β)进行了评估。研究还探讨了各项指标与海马和十二个海马亚区体积缩小的关系。结果发现,较高的 HbA1c 或 GA 以及较低的 HOMA-β 水平与多个海马亚区体积较小有着显著的关联。此外,即使我们对非糖尿病患者进行分析,较高的 GA 或较低的 HOMA-β 水平与整个海马或边缘区体积较小之间仍存在实质性关联。我们的研究结果表明,餐后血糖波动、餐后高血糖和低胰岛素分泌对海马体积变小有特定的影响,这表明糖尿病的一级预防和/或充分的血糖控制对预防痴呆症非常重要。
Glucose metabolism and smaller hippocampal volume in elderly people with normal cognitive function.
We investigated associations of glycemic measures, and insulin resistance and secretion measures with hippocampal and subfield volumes. In this cross-sectional study, 7400 community-dwelling participants underwent brain MRI and health checkups between 2016 and 2018. Hemoglobin A1c (HbA1c), glycated albumin (GA), homeostasis model assessment for insulin resistance (HOMA-IR), and HOMA of percent β-cell function (HOMA-β) were evaluated. The associations of each measure with a smaller volume of the hippocampus and twelve hippocampal subfields were investigated. As a result, higher HbA1c or GA and lower HOMA-β levels were significantly associated with smaller volumes in multiple hippocampal subfields. Furthermore, even when we analyzed non-diabetic individuals, substantial associations remained between higher GA or lower HOMA-β levels and smaller volumes of the whole hippocampus or the fimbria. Our findings indicate that postprandial glucose fluctuations, postprandial hyperglycemia, and low insulin secretion have a specific effect on the development of smaller hippocampal volume, suggesting that primary prevention of diabetes and/or sufficient glucose control are important for the prevention of dementia.