S Ma, MC Morris, MJ Hubal, LM Ross, KM Huffman, CG Vann, N Moore, ER Hauser, A Bareja, R Jiang, E Kummerfeld, MD Barberio, JA Houmard, WB Bennett, JL Johnson, JA Timmons, G Broderick, VB Kraus, CF Aliferis, WE Kraus
{"title":"运动对骨骼肌基因表达反应的性别特异性揭示了胰岛素敏感性变化的新型直接介质","authors":"S Ma, MC Morris, MJ Hubal, LM Ross, KM Huffman, CG Vann, N Moore, ER Hauser, A Bareja, R Jiang, E Kummerfeld, MD Barberio, JA Houmard, WB Bennett, JL Johnson, JA Timmons, G Broderick, VB Kraus, CF Aliferis, WE Kraus","doi":"10.1101/2024.09.07.24313236","DOIUrl":null,"url":null,"abstract":"<strong>BACKGROUND</strong> Understanding the causal pathways, systems, and mechanisms through which exercise impacts human health is complex. This study explores molecular signaling related to whole-body insulin sensitivity (Si) by examining changes in skeletal muscle gene expression. The analysis considers differences by biological sex, exercise amount, and exercise intensity to identify potential molecular targets for developing pharmacologic agents that replicate the health benefits of exercise.","PeriodicalId":501419,"journal":{"name":"medRxiv - Endocrinology","volume":"32 1","pages":""},"PeriodicalIF":0.0000,"publicationDate":"2024-09-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":"{\"title\":\"Sex-Specific Skeletal Muscle Gene Expression Responses to Exercise Reveal Novel Direct Mediators of Insulin Sensitivity Change\",\"authors\":\"S Ma, MC Morris, MJ Hubal, LM Ross, KM Huffman, CG Vann, N Moore, ER Hauser, A Bareja, R Jiang, E Kummerfeld, MD Barberio, JA Houmard, WB Bennett, JL Johnson, JA Timmons, G Broderick, VB Kraus, CF Aliferis, WE Kraus\",\"doi\":\"10.1101/2024.09.07.24313236\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<strong>BACKGROUND</strong> Understanding the causal pathways, systems, and mechanisms through which exercise impacts human health is complex. This study explores molecular signaling related to whole-body insulin sensitivity (Si) by examining changes in skeletal muscle gene expression. The analysis considers differences by biological sex, exercise amount, and exercise intensity to identify potential molecular targets for developing pharmacologic agents that replicate the health benefits of exercise.\",\"PeriodicalId\":501419,\"journal\":{\"name\":\"medRxiv - Endocrinology\",\"volume\":\"32 1\",\"pages\":\"\"},\"PeriodicalIF\":0.0000,\"publicationDate\":\"2024-09-08\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"medRxiv - Endocrinology\",\"FirstCategoryId\":\"1085\",\"ListUrlMain\":\"https://doi.org/10.1101/2024.09.07.24313236\",\"RegionNum\":0,\"RegionCategory\":null,\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"\",\"JCRName\":\"\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"medRxiv - Endocrinology","FirstCategoryId":"1085","ListUrlMain":"https://doi.org/10.1101/2024.09.07.24313236","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"","JCRName":"","Score":null,"Total":0}
Sex-Specific Skeletal Muscle Gene Expression Responses to Exercise Reveal Novel Direct Mediators of Insulin Sensitivity Change
BACKGROUND Understanding the causal pathways, systems, and mechanisms through which exercise impacts human health is complex. This study explores molecular signaling related to whole-body insulin sensitivity (Si) by examining changes in skeletal muscle gene expression. The analysis considers differences by biological sex, exercise amount, and exercise intensity to identify potential molecular targets for developing pharmacologic agents that replicate the health benefits of exercise.
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