Mousumi Das, Arindam Biswas, Soumik Goswami, Rajat Deb, Sukdeb Das, Debes Ray
{"title":"西孟加拉邦孟加拉族人群中 PNPLA3 的 rs738409 多态性与非酒精性脂肪肝的发展和严重程度的关系","authors":"Mousumi Das, Arindam Biswas, Soumik Goswami, Rajat Deb, Sukdeb Das, Debes Ray","doi":"10.1101/2024.09.02.24312965","DOIUrl":null,"url":null,"abstract":"<strong>Background and Objectives</strong> Non-alcoholic Fatty Liver Disease (NAFLD) is a common disorder with a complex etiology. Polymorphic variant rs738409 (Ile148Met) in the <em>PNPLA3</em> gene has been reported to be associated with NAFLD among several ethnic populations. The present study aims to identify the potential association of this PNPLA3 gene variant with NAFLD among the ethnic Bengali population of West Bengal and correlate it with disease severity and biochemical parameters.","PeriodicalId":501419,"journal":{"name":"medRxiv - Endocrinology","volume":"10 1","pages":""},"PeriodicalIF":0.0000,"publicationDate":"2024-09-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":"{\"title\":\"Association of the rs738409 polymorphism in PNPLA3 with development and severity of non-alcoholic fatty liver disease in ethnic Bengali population of West Bengal\",\"authors\":\"Mousumi Das, Arindam Biswas, Soumik Goswami, Rajat Deb, Sukdeb Das, Debes Ray\",\"doi\":\"10.1101/2024.09.02.24312965\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<strong>Background and Objectives</strong> Non-alcoholic Fatty Liver Disease (NAFLD) is a common disorder with a complex etiology. Polymorphic variant rs738409 (Ile148Met) in the <em>PNPLA3</em> gene has been reported to be associated with NAFLD among several ethnic populations. The present study aims to identify the potential association of this PNPLA3 gene variant with NAFLD among the ethnic Bengali population of West Bengal and correlate it with disease severity and biochemical parameters.\",\"PeriodicalId\":501419,\"journal\":{\"name\":\"medRxiv - Endocrinology\",\"volume\":\"10 1\",\"pages\":\"\"},\"PeriodicalIF\":0.0000,\"publicationDate\":\"2024-09-03\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"medRxiv - Endocrinology\",\"FirstCategoryId\":\"1085\",\"ListUrlMain\":\"https://doi.org/10.1101/2024.09.02.24312965\",\"RegionNum\":0,\"RegionCategory\":null,\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"\",\"JCRName\":\"\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"medRxiv - Endocrinology","FirstCategoryId":"1085","ListUrlMain":"https://doi.org/10.1101/2024.09.02.24312965","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"","JCRName":"","Score":null,"Total":0}
Association of the rs738409 polymorphism in PNPLA3 with development and severity of non-alcoholic fatty liver disease in ethnic Bengali population of West Bengal
Background and Objectives Non-alcoholic Fatty Liver Disease (NAFLD) is a common disorder with a complex etiology. Polymorphic variant rs738409 (Ile148Met) in the PNPLA3 gene has been reported to be associated with NAFLD among several ethnic populations. The present study aims to identify the potential association of this PNPLA3 gene variant with NAFLD among the ethnic Bengali population of West Bengal and correlate it with disease severity and biochemical parameters.