用于线性颅骨骨折检测的微波技术--利用真实人体头部模型进行的模拟和实验研究

Biosensors Pub Date : 2024-09-06 DOI:10.3390/bios14090434
Mariella Särestöniemi, Daljeet Singh, Mikael von und zu Fraunberg, Teemu Myllylä
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引用次数: 0

摘要

微波(MW)传感技术因其众多优点和开发成医院外使用的便携式设备的潜力,被认为是各种医疗监测和诊断应用中一项很有前途的技术。颅骨骨折的检测及其愈合过程的监测将极大地受益于可在医院外快速、频繁使用的应用。本文首次利用现实模型,对使用 MW 技术检测颅骨骨折进行了基于模拟和实验的研究。它还评估了在工业、科学和医疗(ISM)和超宽带(UWB)范围内最有希望用于颅骨骨折检测的频率范围。评估是通过使用与人体头部不同位置相对应的不同头部组织层模型以及符合解剖学原理的人体头部仿真模型进行的电磁模拟进行的。测量使用的是真实的人体头骨和我们实验室开发的组织模型。综合评估结果表明,骨折会导致天线和通道参数(S11 和 S21)出现明显差异。S11 的差异为 0.1-20 dB,S21 的差异为 0.1-30 dB,具体取决于骨折的宽度和位置。在不同的骨折位置,可以用微波检测到宽度小于 1 毫米的颅骨骨折。可探测性与频率有关。功率流表示法说明了骨折在不同频率下对信号传播的影响。基于微波的颅骨骨折检测提供了以下可能性:(1) 使用安全、低成本的便携式设备检测骨折;(2) 监测骨折的愈合过程;(3) 为可检测中风等疾病的新兴便携式微波诊断应用提供重要信息。
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Microwave Technique for Linear Skull Fracture Detection—Simulation and Experimental Study Using Realistic Human Head Models
Microwave (MW) sensing is regarded as a promising technique for various medical monitoring and diagnostic applications due to its numerous advantages and the potential to be developed into a portable device for use outside hospital settings. The detection of skull fractures and the monitoring of their healing process would greatly benefit from a rapidly and frequently usable application that can be employed outside the hospital. This paper presents a simulation- and experiment-based study on skull fracture detection with the MW technique using realistic models for the first time. It also presents assessments on the most promising frequency ranges for skull fracture detection within the Industrial, Scientific and Medical (ISM) and ultrawideband (UWB) ranges. Evaluations are carried out with electromagnetic simulations using different head tissue layer models corresponding to different locations in the human head, as well as an anatomically realistic human head simulation model. The measurements are conducted with a real human skull combined with tissue phantoms developed in our laboratory. The comprehensive evaluations show that fractures cause clear differences in antenna and channel parameters (S11 and S21). The difference in S11 is 0.1–20 dB and in S21 is 0.1–30 dB, depending on the fracture width and location. Skull fractures with a less than 1 mm width can be detected with microwaves at different fracture locations. The detectability is frequency dependent. Power flow representations illustrate how fractures impact on the signal propagation at different frequencies. MW-based detection of skull fractures provides the possibility to (1) detect fractures using a safe and low-cost portable device, (2) monitor the healing-process of fractures, and (3) bring essential information for emerging portable MW-based diagnostic applications that can detect, e.g., strokes.
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