Sara Mehrez, Mustafa Ahmed Neamatallah, Zeinab Gomaa, Abdel-Hady El-Gilany, Mohammed Shahda, Hiam F Elsaied
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引用次数: 0
摘要
强迫症(OCD)是一种使人衰弱的疾病,其病因是多因素的,包括遗传、神经生物学、认知和环境影响。遗传学研究主要集中在血清素系统的基因上。本研究旨在寻找埃及人群中血清素转运体基因启动子区域的多态性与强迫症之间可能存在的关系。这项研究包括 94 名强迫症患者和 116 名健康对照者。研究人员采集了所有参与者的血液样本,用于 DNA 提取和基因分型。根据 DSM-V 和耶鲁-布朗强迫症量表对患者进行了结构化临床访谈评估。血清素转运体基因多态性与强迫症的发展存在关联。短等位基因携带者是患强迫症的危险因素。强迫症与血清素转运体基因多态性有关。这将有助于考虑患者的遗传信息,通过个性化治疗选择来预测最佳药物反应和耐受性。
Association between serotonin transporter gene polymorphism and obsessive–compulsive disorder in the Egyptian population
Obsessive–compulsive disorder (OCD) is a debilitating disorder that has multifactorial etiology including genetic, neurobiological, cognitive, and environmental influences. Genetic studies have focused on the genes of the serotonin system. This study aimed to look for the possible relation between the polymorphism in the promotor region of the serotonin transporter gene and obsessive–compulsive disorder in the Egyptian population. This study included 94 OCD patients and 116 healthy control individuals. Blood samples were collected from all participants for DNA extraction and genotyping. The assessment of patients was done by application of the structured clinical interview according to DSM-V, the dimensional Yale-Brown Obsessive–Compulsive Scale. There was an association between serotonin transporter gene polymorphism and OCD development. The carriage of the short allele was a risk factor for having OCD. Obsessive–compulsive disorder is associated with serotonin transporter gene polymorphism. This will contribute to considering the genetic information of patients for the prediction of best drug response and tolerability by personalizing the choice of treatment.