不健全的颈部瓣膜威胁老化的大脑

IF 17 Q1 CELL BIOLOGY Nature aging Pub Date : 2024-09-11 DOI:10.1038/s43587-024-00707-y
Monica M. Santisteban, Costantino Iadecola
{"title":"不健全的颈部瓣膜威胁老化的大脑","authors":"Monica M. Santisteban, Costantino Iadecola","doi":"10.1038/s43587-024-00707-y","DOIUrl":null,"url":null,"abstract":"Cervical lymphatic vessels drain cerebrospinal fluid from the brain. A recent study reveals an aging-related disruption in the pumping action of lymphatic vessels that hampers lymph flow, which may prevent efficient brain clearance of potentially toxic proteins linked to neurodegenerative disease.","PeriodicalId":94150,"journal":{"name":"Nature aging","volume":null,"pages":null},"PeriodicalIF":17.0000,"publicationDate":"2024-09-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":"{\"title\":\"Incompetent neck valves threaten the aging brain\",\"authors\":\"Monica M. Santisteban, Costantino Iadecola\",\"doi\":\"10.1038/s43587-024-00707-y\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"Cervical lymphatic vessels drain cerebrospinal fluid from the brain. A recent study reveals an aging-related disruption in the pumping action of lymphatic vessels that hampers lymph flow, which may prevent efficient brain clearance of potentially toxic proteins linked to neurodegenerative disease.\",\"PeriodicalId\":94150,\"journal\":{\"name\":\"Nature aging\",\"volume\":null,\"pages\":null},\"PeriodicalIF\":17.0000,\"publicationDate\":\"2024-09-11\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Nature aging\",\"FirstCategoryId\":\"1085\",\"ListUrlMain\":\"https://www.nature.com/articles/s43587-024-00707-y\",\"RegionNum\":0,\"RegionCategory\":null,\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"Q1\",\"JCRName\":\"CELL BIOLOGY\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Nature aging","FirstCategoryId":"1085","ListUrlMain":"https://www.nature.com/articles/s43587-024-00707-y","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q1","JCRName":"CELL BIOLOGY","Score":null,"Total":0}
引用次数: 0

摘要

颈淋巴管从大脑排出脑脊液。最近的一项研究发现,淋巴管的泵送作用会因衰老而中断,从而阻碍淋巴流动,这可能会妨碍大脑有效清除与神经退行性疾病相关的潜在毒性蛋白质。
本文章由计算机程序翻译,如有差异,请以英文原文为准。

摘要图片

摘要图片

查看原文
分享 分享
微信好友 朋友圈 QQ好友 复制链接
本刊更多论文
Incompetent neck valves threaten the aging brain
Cervical lymphatic vessels drain cerebrospinal fluid from the brain. A recent study reveals an aging-related disruption in the pumping action of lymphatic vessels that hampers lymph flow, which may prevent efficient brain clearance of potentially toxic proteins linked to neurodegenerative disease.
求助全文
通过发布文献求助,成功后即可免费获取论文全文。 去求助
来源期刊
CiteScore
14.70
自引率
0.00%
发文量
0
期刊最新文献
Modifiable risk factors of dementia in Latin America. Phenome-wide associations of human aging uncover sex-specific dynamics. Lessons from the HEALEY adaptive platform trial in amyotrophic lateral sclerosis. Rejuvenating older neural stem cells. Retraction Note: KDM4 orchestrates epigenomic remodeling of senescent cells and potentiates the senescence-associated secretory phenotype.
×
引用
GB/T 7714-2015
复制
MLA
复制
APA
复制
导出至
BibTeX EndNote RefMan NoteFirst NoteExpress
×
×
提示
您的信息不完整,为了账户安全,请先补充。
现在去补充
×
提示
您因"违规操作"
具体请查看互助需知
我知道了
×
提示
现在去查看 取消
×
提示
确定
0
微信
客服QQ
Book学术公众号 扫码关注我们
反馈
×
意见反馈
请填写您的意见或建议
请填写您的手机或邮箱
已复制链接
已复制链接
快去分享给好友吧!
我知道了
×
扫码分享
扫码分享
Book学术官方微信
Book学术文献互助
Book学术文献互助群
群 号:481959085
Book学术
文献互助 智能选刊 最新文献 互助须知 联系我们:info@booksci.cn
Book学术提供免费学术资源搜索服务,方便国内外学者检索中英文文献。致力于提供最便捷和优质的服务体验。
Copyright © 2023 Book学术 All rights reserved.
ghs 京公网安备 11010802042870号 京ICP备2023020795号-1