概率接触追踪在遏制疫情中的有效性:超级传播者和传播路径重建的作用

Anna Paola Muntoni, Fabio Mazza, Alfredo Braunstein, Giovanni Catania, Luca Dall'Asta
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摘要

最近的 COVID-19 大流行凸显了早期非药物干预策略的重要性。口罩的广泛使用和接触者追踪策略的系统实施,提供了一个潜在的同样有效且对社会影响较小的替代方法,而不是更传统的方法,如大规模的流动限制。然而,人工接触追踪在访问接触者网络方面面临很大的局限性,而在疫情迅速扩大的阶段,由于接触通知和相关检测的激增,目前实施的基于智能手机的数字接触追踪协议的可扩展性变得不切实际。通过整合风险评估的概率技术,可以更有效地指导新诊断测试的分配,从而大大改进数字接触追踪技术。在本研究中,我们首先采用三种最先进的 SARS-CoV-2 传播模型,定量分析了与这些基于接触追踪的遏制措施相关的诊断和社会成本。我们的结果表明,概率技术能以更低的成本实现更有效的缓解。其次,我们的研究结果表明,概率接触追踪技术在进行后向和多步追踪以及捕捉超级传播事件方面具有显著的功效。
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Effectiveness of probabilistic contact tracing in epidemic containment: The role of super-spreaders and transmission path reconstruction
The recent COVID-19 pandemic underscores the significance of early-stage non-pharmacological intervention strategies. The widespread use of masks and the systematic implementation of contact tracing strategies provide a potentially equally effective and socially less impactful alternative to more conventional approaches, such as large-scale mobility restrictions. However, manual contact tracing faces strong limitations in accessing the network of contacts, and the scalability of currently implemented protocols for smartphone-based digital contact tracing becomes impractical during the rapid expansion phases of the outbreaks, due to the surge in exposure notifications and associated tests. A substantial improvement in digital contact tracing can be obtained through the integration of probabilistic techniques for risk assessment that can more effectively guide the allocation of new diagnostic tests. In this study, we first quantitatively analyze the diagnostic and social costs associated with these containment measures based on contact tracing, employing three state-of-the-art models of SARS-CoV-2 spreading. Our results suggest that probabilistic techniques allow for more effective mitigation at a lower cost. Secondly, our findings reveal a remarkable efficacy of probabilistic contact-tracing techniques in performing backward and multi-step tracing and capturing super-spreading events.
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