童年逆境与青少年表观遗传年龄加速：青少年睡眠健康的作用

medRxiv - Psychiatry and Clinical Psychology Pub Date : 2024-09-05 DOI:10.1101/2024.09.02.24312939

Karissa DiMarzio, Darlynn M. Rojo-Wissar, Evelyn Hernandez Valencia, Mikayla Ver Pault, Shane Denherder, Adamari Lopez, Jena Lerch, Georgette Metrailer, Sarah M. Merrill, April Highlander, Justin Parent

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引用次数: 0

摘要

研究目的我们调查了早期生活逆境（ELA）的一个维度，即家庭中的威胁如何通过睡眠（持续时间、效率和时间）与青少年后期的表观遗传年龄加速相关联，从而对理论模型进行实证检验，该模型表明睡眠的重要性是将 ELA 与不良健康结果联系起来的一个关键机制，并扩展了有关青少年睡眠和表观遗传衰老的有限文献。

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Childhood Adversity and Adolescent Epigenetic Age Acceleration: The Role of Adolescent Sleep Health

Study Objectives We investigated how a dimension of early life adversity (ELA) capturing threat in the home relates to later epigenetic age acceleration in adolescence through sleep (duration, efficiency, and timing), to empirically test theoretical models suggesting the importance of sleep as a key mechanism linking ELA with poor health outcomes, and to expand the limited literature on sleep and epigenetic aging among youth.

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medRxiv - Psychiatry and Clinical Psychology

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