系统性红斑狼疮患者因疾病活动和感染而首次住院的预测因素。

IF 1.9 4区 医学 Q3 RHEUMATOLOGY Lupus Pub Date : 2024-09-11 DOI:10.1177/09612033241283551
Guillermo J Pons-Estel,Rosana Quintana,Manuel F Ugarte-Gil,Guillermina B Harvey,Daniel Wojdyla,Rosa Serrano-Morales,José A Gómez Puerta,Mercedes A García,Luis J Catoggio,Verónica Saurit,Cristina Drenkard,Nilzio A Da Silva,Fernando Cavalcanti,Eduardo Borba,Emilia Sato,Oscar Neira,Loreto Massardo,Gloria Vásquez,Luis Alonso Gonzalez,Marlene Guibert-Toledano,Luis H Silveira,Ignacio García De La Torre,María Josefina Sauza Del Pozo,Rosa Chacón,Mario H Cardiel,Ashley Orillion,Urbano Sbarigia,Evo Alemao,Federico Zazzetti,Graciela S Alarcón,Bernardo A Pons-Estel
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Clinical and therapeutic variables were those occurring prior to the first hospitalization. Descriptive statistical tests, multivariable logistic, and Cox regression models were performed.\r\n\r\nRESULTS\r\n1341 individuals were included in this analysis; 1200 (89.5%) were women. Their median and interquartile range (IQR) age at diagnosis were 27 (20-37) years and their median and IQR follow up time were 27.5 (4.7-62.2) months. A total of 456 (34.0%) patients were hospitalized; 344 (75.4%), 85 (18.6%) and 27 (5.9%) for disease activity, infections, or both, respectively. The predictors of the first hospitalization regardless of its cause were: medium (HR 2.03(1.27-3.24); p = 0.0028) and low (HR 2.42(1.55-3.79); p < 0.0001) socioeconomic status, serosal (HR 1.32(1.07-1.62); p = 0.0074) and renal (HR 1.50(1.23-1.82); p < 0.0001) involvement. Antimalarial (AM) use (HR 0.61(0.50-0.74); p < 0.0001) and achieving remission (HR 0.80(0.65-0.97); p = 0.0300) were negative predictors.\r\n\r\nCONCLUSIONS\r\nThe first hospitalization was associated with worse socioeconomic status and serosal and renal involvement. 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引用次数: 0

摘要

目的:研究拉丁美洲队列中红斑狼疮患者首次住院的预测因素,以及与主要住院原因相关的变量。方法:研究这些患者在进入队列后,在随访期间因红斑狼疮疾病活动和/或感染而首次住院的情况。临床和治疗变量为首次住院前发生的变量。结果1341人被纳入分析,其中1200人(89.5%)为女性。她们确诊时的年龄中位数和四分位距(IQR)分别为 27(20-37)岁,随访时间中位数和四分位距(IQR)分别为 27.5(4.7-62.2)个月。共有 456 名(34.0%)患者住院治疗,其中 344 名(75.4%)、85 名(18.6%)和 27 名(5.9%)分别因疾病活动、感染或两者兼有而住院治疗。无论病因如何,首次住院的预测因素均为:中度(HR 2.03(1.27-3.24);p = 0.0028)和低度(HR 2.42(1.55-3.79);p < 0.0001)社会经济状况、血清(HR 1.32(1.07-1.62);p = 0.0074)和肾脏(HR 1.50(1.23-1.82);p < 0.0001)受累。使用抗疟药物(AM)(HR 0.61(0.50-0.74);p < 0.0001)和病情缓解(HR 0.80(0.65-0.97);p = 0.0300)是负面预测因素。相反,使用AM和病情缓解与较低的住院风险有关。
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Predictors of first hospitalization due to disease activity and infections in systemic lupus erythematosus patients.
OBJECTIVES To identify the predictive factors of first hospitalization and associated variables to the main causes of hospitalizations in lupus patients from a Latin American cohort. METHODS The first hospitalization after entry into the cohort during these patients' follow-up due to either lupus disease activity and/or infection was examined. Clinical and therapeutic variables were those occurring prior to the first hospitalization. Descriptive statistical tests, multivariable logistic, and Cox regression models were performed. RESULTS 1341 individuals were included in this analysis; 1200 (89.5%) were women. Their median and interquartile range (IQR) age at diagnosis were 27 (20-37) years and their median and IQR follow up time were 27.5 (4.7-62.2) months. A total of 456 (34.0%) patients were hospitalized; 344 (75.4%), 85 (18.6%) and 27 (5.9%) for disease activity, infections, or both, respectively. The predictors of the first hospitalization regardless of its cause were: medium (HR 2.03(1.27-3.24); p = 0.0028) and low (HR 2.42(1.55-3.79); p < 0.0001) socioeconomic status, serosal (HR 1.32(1.07-1.62); p = 0.0074) and renal (HR 1.50(1.23-1.82); p < 0.0001) involvement. Antimalarial (AM) use (HR 0.61(0.50-0.74); p < 0.0001) and achieving remission (HR 0.80(0.65-0.97); p = 0.0300) were negative predictors. CONCLUSIONS The first hospitalization was associated with worse socioeconomic status and serosal and renal involvement. Conversely, AM use and achieving remission were associated with a lower risk of hospitalizations.
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来源期刊
Lupus
Lupus 医学-风湿病学
CiteScore
4.20
自引率
11.50%
发文量
225
审稿时长
1 months
期刊介绍: The only fully peer reviewed international journal devoted exclusively to lupus (and related disease) research. Lupus includes the most promising new clinical and laboratory-based studies from leading specialists in all lupus-related disciplines. Invaluable reading, with extended coverage, lupus-related disciplines include: Rheumatology, Dermatology, Immunology, Obstetrics, Psychiatry and Cardiovascular Research…
期刊最新文献
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