Guillermo J Pons-Estel,Rosana Quintana,Manuel F Ugarte-Gil,Guillermina B Harvey,Daniel Wojdyla,Rosa Serrano-Morales,José A Gómez Puerta,Mercedes A García,Luis J Catoggio,Verónica Saurit,Cristina Drenkard,Nilzio A Da Silva,Fernando Cavalcanti,Eduardo Borba,Emilia Sato,Oscar Neira,Loreto Massardo,Gloria Vásquez,Luis Alonso Gonzalez,Marlene Guibert-Toledano,Luis H Silveira,Ignacio García De La Torre,María Josefina Sauza Del Pozo,Rosa Chacón,Mario H Cardiel,Ashley Orillion,Urbano Sbarigia,Evo Alemao,Federico Zazzetti,Graciela S Alarcón,Bernardo A Pons-Estel
{"title":"系统性红斑狼疮患者因疾病活动和感染而首次住院的预测因素。","authors":"Guillermo J Pons-Estel,Rosana Quintana,Manuel F Ugarte-Gil,Guillermina B Harvey,Daniel Wojdyla,Rosa Serrano-Morales,José A Gómez Puerta,Mercedes A García,Luis J Catoggio,Verónica Saurit,Cristina Drenkard,Nilzio A Da Silva,Fernando Cavalcanti,Eduardo Borba,Emilia Sato,Oscar Neira,Loreto Massardo,Gloria Vásquez,Luis Alonso Gonzalez,Marlene Guibert-Toledano,Luis H Silveira,Ignacio García De La Torre,María Josefina Sauza Del Pozo,Rosa Chacón,Mario H Cardiel,Ashley Orillion,Urbano Sbarigia,Evo Alemao,Federico Zazzetti,Graciela S Alarcón,Bernardo A Pons-Estel","doi":"10.1177/09612033241283551","DOIUrl":null,"url":null,"abstract":"OBJECTIVES\r\nTo identify the predictive factors of first hospitalization and associated variables to the main causes of hospitalizations in lupus patients from a Latin American cohort.\r\n\r\nMETHODS\r\nThe first hospitalization after entry into the cohort during these patients' follow-up due to either lupus disease activity and/or infection was examined. Clinical and therapeutic variables were those occurring prior to the first hospitalization. Descriptive statistical tests, multivariable logistic, and Cox regression models were performed.\r\n\r\nRESULTS\r\n1341 individuals were included in this analysis; 1200 (89.5%) were women. Their median and interquartile range (IQR) age at diagnosis were 27 (20-37) years and their median and IQR follow up time were 27.5 (4.7-62.2) months. A total of 456 (34.0%) patients were hospitalized; 344 (75.4%), 85 (18.6%) and 27 (5.9%) for disease activity, infections, or both, respectively. The predictors of the first hospitalization regardless of its cause were: medium (HR 2.03(1.27-3.24); p = 0.0028) and low (HR 2.42(1.55-3.79); p < 0.0001) socioeconomic status, serosal (HR 1.32(1.07-1.62); p = 0.0074) and renal (HR 1.50(1.23-1.82); p < 0.0001) involvement. Antimalarial (AM) use (HR 0.61(0.50-0.74); p < 0.0001) and achieving remission (HR 0.80(0.65-0.97); p = 0.0300) were negative predictors.\r\n\r\nCONCLUSIONS\r\nThe first hospitalization was associated with worse socioeconomic status and serosal and renal involvement. Conversely, AM use and achieving remission were associated with a lower risk of hospitalizations.","PeriodicalId":18044,"journal":{"name":"Lupus","volume":"44 1","pages":"9612033241283551"},"PeriodicalIF":1.9000,"publicationDate":"2024-09-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":"{\"title\":\"Predictors of first hospitalization due to disease activity and infections in systemic lupus erythematosus patients.\",\"authors\":\"Guillermo J Pons-Estel,Rosana Quintana,Manuel F Ugarte-Gil,Guillermina B Harvey,Daniel Wojdyla,Rosa Serrano-Morales,José A Gómez Puerta,Mercedes A García,Luis J Catoggio,Verónica Saurit,Cristina Drenkard,Nilzio A Da Silva,Fernando Cavalcanti,Eduardo Borba,Emilia Sato,Oscar Neira,Loreto Massardo,Gloria Vásquez,Luis Alonso Gonzalez,Marlene Guibert-Toledano,Luis H Silveira,Ignacio García De La Torre,María Josefina Sauza Del Pozo,Rosa Chacón,Mario H Cardiel,Ashley Orillion,Urbano Sbarigia,Evo Alemao,Federico Zazzetti,Graciela S Alarcón,Bernardo A Pons-Estel\",\"doi\":\"10.1177/09612033241283551\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"OBJECTIVES\\r\\nTo identify the predictive factors of first hospitalization and associated variables to the main causes of hospitalizations in lupus patients from a Latin American cohort.\\r\\n\\r\\nMETHODS\\r\\nThe first hospitalization after entry into the cohort during these patients' follow-up due to either lupus disease activity and/or infection was examined. Clinical and therapeutic variables were those occurring prior to the first hospitalization. Descriptive statistical tests, multivariable logistic, and Cox regression models were performed.\\r\\n\\r\\nRESULTS\\r\\n1341 individuals were included in this analysis; 1200 (89.5%) were women. Their median and interquartile range (IQR) age at diagnosis were 27 (20-37) years and their median and IQR follow up time were 27.5 (4.7-62.2) months. A total of 456 (34.0%) patients were hospitalized; 344 (75.4%), 85 (18.6%) and 27 (5.9%) for disease activity, infections, or both, respectively. The predictors of the first hospitalization regardless of its cause were: medium (HR 2.03(1.27-3.24); p = 0.0028) and low (HR 2.42(1.55-3.79); p < 0.0001) socioeconomic status, serosal (HR 1.32(1.07-1.62); p = 0.0074) and renal (HR 1.50(1.23-1.82); p < 0.0001) involvement. Antimalarial (AM) use (HR 0.61(0.50-0.74); p < 0.0001) and achieving remission (HR 0.80(0.65-0.97); p = 0.0300) were negative predictors.\\r\\n\\r\\nCONCLUSIONS\\r\\nThe first hospitalization was associated with worse socioeconomic status and serosal and renal involvement. Conversely, AM use and achieving remission were associated with a lower risk of hospitalizations.\",\"PeriodicalId\":18044,\"journal\":{\"name\":\"Lupus\",\"volume\":\"44 1\",\"pages\":\"9612033241283551\"},\"PeriodicalIF\":1.9000,\"publicationDate\":\"2024-09-11\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Lupus\",\"FirstCategoryId\":\"3\",\"ListUrlMain\":\"https://doi.org/10.1177/09612033241283551\",\"RegionNum\":4,\"RegionCategory\":\"医学\",\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"Q3\",\"JCRName\":\"RHEUMATOLOGY\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Lupus","FirstCategoryId":"3","ListUrlMain":"https://doi.org/10.1177/09612033241283551","RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q3","JCRName":"RHEUMATOLOGY","Score":null,"Total":0}
Predictors of first hospitalization due to disease activity and infections in systemic lupus erythematosus patients.
OBJECTIVES
To identify the predictive factors of first hospitalization and associated variables to the main causes of hospitalizations in lupus patients from a Latin American cohort.
METHODS
The first hospitalization after entry into the cohort during these patients' follow-up due to either lupus disease activity and/or infection was examined. Clinical and therapeutic variables were those occurring prior to the first hospitalization. Descriptive statistical tests, multivariable logistic, and Cox regression models were performed.
RESULTS
1341 individuals were included in this analysis; 1200 (89.5%) were women. Their median and interquartile range (IQR) age at diagnosis were 27 (20-37) years and their median and IQR follow up time were 27.5 (4.7-62.2) months. A total of 456 (34.0%) patients were hospitalized; 344 (75.4%), 85 (18.6%) and 27 (5.9%) for disease activity, infections, or both, respectively. The predictors of the first hospitalization regardless of its cause were: medium (HR 2.03(1.27-3.24); p = 0.0028) and low (HR 2.42(1.55-3.79); p < 0.0001) socioeconomic status, serosal (HR 1.32(1.07-1.62); p = 0.0074) and renal (HR 1.50(1.23-1.82); p < 0.0001) involvement. Antimalarial (AM) use (HR 0.61(0.50-0.74); p < 0.0001) and achieving remission (HR 0.80(0.65-0.97); p = 0.0300) were negative predictors.
CONCLUSIONS
The first hospitalization was associated with worse socioeconomic status and serosal and renal involvement. Conversely, AM use and achieving remission were associated with a lower risk of hospitalizations.
期刊介绍:
The only fully peer reviewed international journal devoted exclusively to lupus (and related disease) research. Lupus includes the most promising new clinical and laboratory-based studies from leading specialists in all lupus-related disciplines. Invaluable reading, with extended coverage, lupus-related disciplines include: Rheumatology, Dermatology, Immunology, Obstetrics, Psychiatry and Cardiovascular Research…