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引用次数: 0
摘要
目前正在研究开发预防和治疗单纯疱疹病毒(HSV)感染的疫苗。该研究强调了通过免疫接种来解决公共卫生问题的迫切需要,以及现有治疗方案的不足之处。此外,对单纯疱疹病毒疫苗的研究推动了免疫学和疫苗创造领域的发展,这可能有助于对抗其他病毒性疾病。目前缺乏这种疫苗的部分原因是疱疹病毒潜伏在感觉神经节中。目前的疫苗依赖于组织驻留的记忆性 CD8+ T 细胞,众所周知,这种细胞能提供对后续 HSV 再感染和再活化的保护,但与其他免疫亚群无关。因此,目前还没有一种有效的疫苗能为潜伏或复发性疱疹感染提供保护。本综述将重点介绍利用CD8+ T细胞差异评估疱疹疫苗疗效的传统方法,以及设计有效疱疹疫苗的重要的未考虑免疫因素。
Immunological Considerations for the Development of an Effective Herpes Vaccine
Research is underway to develop a vaccine to prevent and cure infection from herpes simplex virus (HSV). It emphasizes the critical need for immunization to address public health issues and the shortcomings of existing treatment options. Furthermore, studies on the HSV vaccine advance the field of immunology and vaccine creation, which may help in the battle against other viral illnesses. The current lack of such a vaccine is, in part, due to herpes viral latency in sensory ganglions. Current vaccines rely on tissue-resident memory CD8+ T cells, which are known to provide protection against subsequent HSV reinfection and reactivation without correlating with other immune subsets. For that reason, there is no effective vaccine that can provide protection against latent or recurrent herpes infection. This review focuses on conventional methods for evaluating the efficacy of a herpes vaccine using differential CD8+ T cells and important unaccounted immune aspects for designing an effective vaccine against herpes.
期刊介绍:
Microorganisms (ISSN 2076-2607) is an international, peer-reviewed open access journal which provides an advanced forum for studies related to prokaryotic and eukaryotic microorganisms, viruses and prions. It publishes reviews, research papers and communications. Our aim is to encourage scientists to publish their experimental and theoretical results in as much detail as possible. There is no restriction on the length of the papers. The full experimental details must be provided so that the results can be reproduced. Electronic files and software regarding the full details of the calculation or experimental procedure, if unable to be published in a normal way, can be deposited as supplementary electronic material.