二元混合物中的分离与活性环之间的差异收缩

Emanuel F. Teixeira, Carine P. Beatrici, Heitor C. M. Fernandes, Leonardo G. Brunnet
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引用次数: 0

摘要

细胞皮层的收缩对于塑造细胞、实现运动、确保正常分裂、保持组织完整性、指导发育以及对机械信号做出反应至关重要,所有这些对于多细胞生物的生命和健康都至关重要。细胞膜的不同收缩,尤其是当不同类型的细胞相互作用时,在分离的产生中起着至关重要的作用。在本研究中,我们引入了一个模型,在该模型中,由活性粒子组成的环通过在指定的截断距离内的不同膜收缩而相互作用。我们证明,分离完全源于不同的收缩,环的活性与有效温度的作用类似。此外,我们还观察到分离涉及到集群融合-扩散过程。然而,我们发现偏析参数的衰减指数接近于$\lambda \sim-1/3$,这与之前的理论方法和模拟预测的$\lambda \sim-1/4$有所不同。
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Segregation in binary mixture with differential contraction among active rings
Cell cortex contraction is essential for shaping cells, enabling movement, ensuring proper division, maintaining tissue integrity, guiding development, and responding to mechanical signals - all critical for the life and health of multicellular organisms. Differential contractions in cell membranes, particularly when cells of different types interact, play a crucial role in the emergence of segregation. In this study, we introduce a model where rings composed of active particles interact through differential membrane contraction within a specified cutoff distance. We demonstrate that segregation arises solely from differential contraction, with the activity of the rings functioning similarly to an effective temperature. Additionally, we observed that segregation involves cluster fusion-diffusion process. However, the decay exponent of the segregation parameter we found is close to $\lambda \sim -1/3$, which differs from the $\lambda \sim -1/4$ predicted by previous theoretical approaches and simulations.
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