免疫检查点抑制剂治疗引起的多种胃肠道免疫相关不良事件。

IF 3 3区医学 Q2 GASTROENTEROLOGY & HEPATOLOGY Clinical and Translational Gastroenterology Pub Date : 2024-09-12 DOI:10.14309/ctg.0000000000000768

Trevor S Barlowe,Shruti Saxena-Beem,Rumey C Ishizawar,Hans Herfarth,Andrew M Moon

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引用次数: 0

摘要

目的描述接受免疫检查点抑制剂（ICI）治疗的患者发生的影响胃肠道系统多个器官的免疫相关不良事件（irAE）。方法在由接受 ICIs 治疗的癌症患者组成的 2843 例患者回顾性队列中，使用信息检索系统 EMERSE（电子病历搜索引擎）搜索病历中的自由文本，以识别出现多种胃肠道 irAEs 的患者。结果13 例患者出现多种胃肠道 irAEs（0.46%）。结肠炎+胰腺炎和结肠炎+肠炎是最常见的多系统胃肠道虹吸效应模式。

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Multiple gastrointestinal immune related adverse events from immune checkpoint inhibitor therapy.

OBJECTIVES Describe immune related adverse events (irAE) affecting multiple organs of the gastrointestinal system in patients who received immune checkpoint inhibitors (ICI). METHODS Within a 2843-patient retrospective cohort consisting of patients with cancer treated with ICIs, EMERSE (Electronic Medical Record Search Engine), an information retrieval system, was used to search free text in the medical record to identify patients with multiple gastrointestinal irAEs. RESULTS 13 patients developed multiple gastrointestinal irAEs (0.46%). The most common patterns of multisystem gastrointestinal irAE were colitis + pancreatitis and colitis + enteritis. CONCLUSIONS Multisystem gastrointestinal irAEs are rare but warrant further characterization and attention.

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来源期刊

Clinical and Translational Gastroenterology GASTROENTEROLOGY & HEPATOLOGY-

CiteScore

7.00

自引率

0.00%

发文量

114

审稿时长

16 weeks

期刊介绍： Clinical and Translational Gastroenterology (CTG), published on behalf of the American College of Gastroenterology (ACG), is a peer-reviewed open access online journal dedicated to innovative clinical work in the field of gastroenterology and hepatology. CTG hopes to fulfill an unmet need for clinicians and scientists by welcoming novel cohort studies, early-phase clinical trials, qualitative and quantitative epidemiologic research, hypothesis-generating research, studies of novel mechanisms and methodologies including public health interventions, and integration of approaches across organs and disciplines. CTG also welcomes hypothesis-generating small studies, methods papers, and translational research with clear applications to human physiology or disease. Colon and small bowel Endoscopy and novel diagnostics Esophagus Functional GI disorders Immunology of the GI tract Microbiology of the GI tract Inflammatory bowel disease Pancreas and biliary tract Liver Pathology Pediatrics Preventative medicine Nutrition/obesity Stomach.