微波辐照下在 H-Clinoptilolite 存在下合成对乙酰氨基酚

IF 0.8 4区医学 Q4 CHEMISTRY, MEDICINAL Pharmaceutical Chemistry Journal Pub Date : 2024-08-15 DOI:10.1007/s11094-024-03193-z

G. H. Torosyan, P. A. Yesayan, H. H. Aleksanyan

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引用次数: 0

摘要

为了继续寻找有效、经济和环保的对乙酰氨基酚（扑热息痛）合成方法，我们研究了在 H-clinoptilolite 存在下微波辐照下对氨基苯酚与乙酸酐的反应。实验证明，所提出的系统能够快速合成这种最重要的药物，而且产量高、纯度高。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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Synthesis of Acetaminophen Under Microwave Irradiation in the Presence of H-Clinoptilolite

The reaction of p-aminophenol with acetic anhydride under microwave irradiation in the presence of H-clinoptilolite was studied to continue the search for effective, economically favorable, and environmentally friendly methods for synthesizing acetaminophen (paracetamol). The proposed system, which provided a rapid synthesis of the most important drug with a high yield and purity, was demonstrated to be efficient.

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来源期刊

Pharmaceutical Chemistry Journal CHEMISTRY, MEDICINAL-PHARMACOLOGY & PHARMACY

CiteScore

1.30

自引率

22.20%

发文量

226

审稿时长

3-8 weeks

期刊介绍： Pharmaceutical Chemistry Journal is a monthly publication devoted to scientific and technical research on the creation of new drugs and the improvement of manufacturing technology of drugs and intermediates. International contributors cover the entire spectrum of new drug research, including: methods of synthesis; results of pharmacological, toxicological, and biochemical studies; investigation of structure - activity relationships in prediction of new compounds; methods and technical facilities used; and problems associated with the development of ecologically safe and economically feasible methods of industrial production. In addition, analytical reviews of the international literature in the field provide coverage of the most recent developments around the world. Pharmaceutical Chemistry Journal is a translation of the Russian journal Khimiko-Farmatsevticheskii Zhurnal. The Russian Volume Year is published in English from April. All articles are peer-reviewed.