异汀类不对称加成反应的最新进展

Synthesis Pub Date : 2024-08-22 DOI:10.1055/a-2376-6463
Ke Xie, Ao Li, Bao-Rui Kong, Zhi-Chao Chen, Wei Du, Ying-Chun Chen
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引用次数: 0

摘要

3-取代-3-羟基-2-吲哚支架不仅广泛存在于生物活性化合物中,而且还是构建各种有价值结构的多功能构件。尽管在过去几十年中已经开发出了许多合成方法,但事实证明,将亲核物或其等价物不对称地加成到异靛基质上是合成手性 3-取代-3-羟基-2-吲哚的最有效策略之一。本短评旨在总结近年来该领域取得的重大进展,尤其关注反应发展、机理和立体诱导模型。1 引言 2 异靛红的非对称烷基化 3 异靛红的非对称烯基化和二烯丙基化 4 异靛红的非对称炔基化 5 异靛红的非对称烯丙基化 6 异靛红的非对称芳基化 7 异靛红的非对称环化 8 结论与展望
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Recent Advances in Asymmetric Addition Reactions to Isatins

The 3-substituted-3-hydroxy-2-oxindole scaffolds are not only widely encountered in bioactive compounds but also serve as versatile building blocks for the construction of diverse valuable architectures. Although numerous synthetic methodologies have been developed over the past decades, the asymmetric addition of nucleophiles or their equivalents to isatin substrates has proved to be one of the most efficient strategies for the synthesis of chiral 3-substituted-3-hydroxy-2-oxindoles. This Short Review aims to summarize the significant progress achieved in this field in recent years, with particular attention paid to reaction development, mechanism, and stereo-induction models.

1 Introduction

2 Asymmetric Alkylation of Isatins

3 Asymmetric Alkenylation and Dienylation of Isatins

4 Asymmetric Alkynylation of Isatins

5 Asymmetric Allenylation of Isatins

6 Asymmetric Arylation of Isatins

7 Asymmetric Annulations of Isatins

8 Conclusions and Outlooks

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