{"title":"用植物乳杆菌 MWFLp-182 喂养活体或热处理杀死的小鼠，可抑制鼠伤寒沙门氏菌感染","authors":"Jia Liu, Peng Sun, Zihan Jin, Hui Nie, Guangqing Mu, Xiaomeng Wu","doi":"10.1111/1471-0307.13131","DOIUrl":null,"url":null,"abstract":"The effects of both live and heat‐killed states of <jats:italic>Lactiplantibacillus plantarum</jats:italic> MWFLp‐182 (<jats:italic>L. plantarum</jats:italic> MWFLp‐182) isolated from the faeces of long‐lived humans on preventing and relieving <jats:italic>Salmonella</jats:italic> infection were studied. Evaluation methods included RT‐qPCR measurement of inflammatory factors, histopathological analysis and non‐targeted metabolomics. The results showed that <jats:italic>L. plantarum</jats:italic> MWFLp‐182 in both states improved body weight loss, organ swelling and ileocolon pathological damage. They also protected against <jats:italic>Salmonella</jats:italic> infection by regulating key KEGG enrichment pathways and the expression levels of TNF‐a and IL‐6. It is worth noting that the function of live bacteria was better than that of heat‐killed bacteria.","PeriodicalId":13822,"journal":{"name":"International Journal of Dairy Technology","volume":null,"pages":null},"PeriodicalIF":2.5000,"publicationDate":"2024-08-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":"{\"title\":\"Inhibition of Salmonella typhimurium infection in mice fed with live or heat‐killed Lactiplantibacillus plantarum MWFLp‐182\",\"authors\":\"Jia Liu, Peng Sun, Zihan Jin, Hui Nie, Guangqing Mu, Xiaomeng Wu\",\"doi\":\"10.1111/1471-0307.13131\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"The effects of both live and heat‐killed states of <jats:italic>Lactiplantibacillus plantarum</jats:italic> MWFLp‐182 (<jats:italic>L. plantarum</jats:italic> MWFLp‐182) isolated from the faeces of long‐lived humans on preventing and relieving <jats:italic>Salmonella</jats:italic> infection were studied. Evaluation methods included RT‐qPCR measurement of inflammatory factors, histopathological analysis and non‐targeted metabolomics. The results showed that <jats:italic>L. plantarum</jats:italic> MWFLp‐182 in both states improved body weight loss, organ swelling and ileocolon pathological damage. They also protected against <jats:italic>Salmonella</jats:italic> infection by regulating key KEGG enrichment pathways and the expression levels of TNF‐a and IL‐6. It is worth noting that the function of live bacteria was better than that of heat‐killed bacteria.\",\"PeriodicalId\":13822,\"journal\":{\"name\":\"International Journal of Dairy Technology\",\"volume\":null,\"pages\":null},\"PeriodicalIF\":2.5000,\"publicationDate\":\"2024-08-28\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"International Journal of Dairy Technology\",\"FirstCategoryId\":\"97\",\"ListUrlMain\":\"https://doi.org/10.1111/1471-0307.13131\",\"RegionNum\":2,\"RegionCategory\":\"农林科学\",\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"Q3\",\"JCRName\":\"FOOD SCIENCE & TECHNOLOGY\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"International Journal of Dairy Technology","FirstCategoryId":"97","ListUrlMain":"https://doi.org/10.1111/1471-0307.13131","RegionNum":2,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q3","JCRName":"FOOD SCIENCE & TECHNOLOGY","Score":null,"Total":0}
Inhibition of Salmonella typhimurium infection in mice fed with live or heat‐killed Lactiplantibacillus plantarum MWFLp‐182
The effects of both live and heat‐killed states of Lactiplantibacillus plantarum MWFLp‐182 (L. plantarum MWFLp‐182) isolated from the faeces of long‐lived humans on preventing and relieving Salmonella infection were studied. Evaluation methods included RT‐qPCR measurement of inflammatory factors, histopathological analysis and non‐targeted metabolomics. The results showed that L. plantarum MWFLp‐182 in both states improved body weight loss, organ swelling and ileocolon pathological damage. They also protected against Salmonella infection by regulating key KEGG enrichment pathways and the expression levels of TNF‐a and IL‐6. It is worth noting that the function of live bacteria was better than that of heat‐killed bacteria.
期刊介绍：
The International Journal of Dairy Technology ranks highly among the leading dairy journals published worldwide, and is the flagship of the Society. As indicated in its title, the journal is international in scope.
Published quarterly, International Journal of Dairy Technology contains original papers and review articles covering topics that are at the interface between fundamental dairy research and the practical technological challenges facing the modern dairy industry worldwide. Topics addressed span the full range of dairy technologies, the production of diverse dairy products across the world and the development of dairy ingredients for food applications.
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